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Text description provided by the architects. Dayuan, the founder of the school, was once one of the best middle school linguistics teachers, later he became a businessman due to peculiar encounters. However, there is always a dream about education in his heart. For the olive tree in his dreams, he finally set off after many years of preparation.international school in hangzhou

After several discussions and inevitable collisions of ideas, the architects determined the overall layout:
The buildings and the sports areas take one half of the site each. Although the east-west oriented track and the dormitories are not common, the overall structure is compact, well responding to the high-speed train line, the highway entrance on the south and the main urban boulevard on the west.
All the art and experience spaces are located on the ground floor; Public spaces such as roof gardens, vegetable gardens, science museum are on the top floor; Classrooms and offices are located on the floors in-between.

The ideal school buildings in Dayuan’s mind should have conversations between western and eastern cultures, and inherit the spirit from both the old times and new days. Below are the architects’ considerations and responses:

Courtyard is a basic spatial element that is common in all kinds of cultures in ancient and modern China and abroad.
Pitched roof is a basic form in the culture at all times and in all over the world.Chinese tradition is to enter the building from the eave side; whereas the western world from the gable wall.

Arch is an important element of Western classical architecture; to place buildings along the south-north axis and form a layered courtyard is a common method for classical Chinese architecture.The red brick façade is a common practice in Western architecture; whilethe white wall is widely used in classical architecture in the Jiangnan area.

The primary school has two layers of courtyards with the theme of nature; three olive trees from the Mediterranean are planted in the high school courtyard with red brick walls on four sides; white walls with light wooden colored railing and roof structure are used in middle school courtyard; there is a pool of water in between middle school and high school, with eight types of aquatic plants native to Jiangnan. Olive tree represents Global vision, “Shuibaxian” (eight types of aquatic plants) reflects Chinese feeing and native sentiment.

There is a river in the east of the site, so a bridge that meets the functions is needed. The international school curriculum attends to both Chinese and Western cultures. A symbolic meaning of ‘connection’ is applied to a functional bridge located on the east side entrance. The complex shape of the continuous integration of the slab of the entrance arch bridge and roof allows the digital design and fabrication to take their advantages.

The perforated pattern of the red brick wall in east façade and the color composition pattern of the west façade of the dormitory source from the same part of the famous Chinese painting, Dwelling in the Fuchun Mountains. Byintegrating digital technology, there is no difficulty to abstract the artistic masterpiece into architectural decorative elements.

The core value of this design is to involve the process and method of architectural design in the basic education process, so as to let the kids who study in the school have the opportunity to learn and experience the different form transition, by combining art and technology.
One of the things I appreciate about you guys is that you set me straight when I have crazy ideas. Yes, maybe in retrospect moving to the Lufthansa First Class Terminal wasn’t the brightest idea ever, though that’s why I run these ideas past you guys before “executing.”living in tianjin

I have another idea, but this time I’m fairly certain it’s genius, though I’ll run it past you guys anyway. I’ve decided to move to Tianjin, China. I know what you’re thinking: what a brilliant idea, go for it! Why Tianjin, you ask?

Well, the St. Regis Tianjin just opened a few months ago, and the rates are rather good, about ~$140USD/night.My plan is to move there and live on the American Express Fine Hotels & Resorts rate, which includes complimentary daily breakfast, guaranteed 4PM check-out, a room upgrade, and a $100 food and beverage credit per stay. Add that to my Starwood Platinum benefits, and I’ll be living the high life for pennies on the dollar.

The only downside is that the food and beverage credit is per stay as opposed to per night, so I guess I’ll have to stay at the Westin every other night. Or maybe I need to move there with a friend and we need to have alternating reservations every other night.
The International School of Tianjin (IST ) is an International Baccalaureate (IB) World School, and the only international school in Tianjin authorized to teach all three IB Programs (Primary Years, Middle Years, and Diploma). IST provides an education of distinction to young global citizens while serving the needs of our communities. The schools comprehensive and coherent written curriculum is based upon the highest academic standards. As a school we use the mission of the IB and the philosophy of IST to guide our deliberations and actions, and to ensure that our children develop the attitudes and dispositions of true internationalists prepared for the challenges and wonders of life beyond our school.international school in Tianjin
An extensive extracurricular activities program is available to students, including the ACAMIS and ISAC inter-school sports leagues, Model United Nations (MUN), Global Issues Network (GIN), Choir and Orchestra, Roots and Shoots, and Student Council.
School Facilities World class, purpose-built school campus, situated on 7.2 hectares of park-like grounds. Including a natural grass football pitch surrounded by 400m running track. An indoor (double-sized) gymnasium with floor-to-ceiling climbing wall. 95 classrooms (equipped with computers, digital projectors and whiteboards), 5 science laboratories, 4 main computer laboratories. Library with extensive collection including a large selection of foreign language books in the following languages: Chinese, Korean, French, German, Danish, Japanese, Spanish, Hindi, Dutch, and Italian.) Dedicated early childhood center with indoor and outdoor play areas. A primary school building and a separate new secondary school building, including a 520-seat theater, black box and extensive music and art suites and design and technology classrooms.
On May 9, the awards ceremony for the 2019 Tianjin Recycling Educational Challenge (TReC) was held at the Himalaya Tianta. This was the TreC program’s 4th year, continuing on its tradition as an educational initiative developed by TJenvironcom and organized by the Tianjin Chapter of AmCham China, where Tianjin's premier international schools participate in a week of recycling and environmental activities. Activities include a recyclables collection drive, as well as an art competition where artwork is composed from recycled materials.Tianjin international school

This year saw participation from Tianjin International School, Wellington Tianjin, Tianjin Yinghua International School (Wuqing and Dongli Campuses), and TEDA International School. Caterpillar Tianjin Ltd., with Anisa Cosmetics sponsoring materials for use in the creation of artwork. Prize sponsors included Ocean Park and the Cambridge Mask Company. Himalaya Tianta Apartments was the venue and awards sponsor

Approx. 1300 kgs of recyclable materials were collected during the week, a year-on-year gain of 69%, and almost 50 works of art were created from materials donated by CAT and Anisa.

Additionally, during his visit to Tianjin on May 7, US Ambassador to China Terry Branstad viewed some of the artwork, and heard from some of the participating students about their thoughts on the environment and the TreC project.

Representatives from the US Embassy Environmental Section, local artists, and representatives from NGOs including Conservation International and the APEC Green Supply Chain Center served as judges in the art segment. The awards ceremony was hosted by TJenvironcom founder Alex Scilla.The TReC-TECC Total [TTT], a tally of the results to date between TReC and it’s sister program TECC (The Tianjin Environmental CSR Challenge) is now ranking in at a recovery total of 3077 kgs of secondary resources, reduced energy usage of over of 30000 kwh, and water savings of over 200 tons.
A school that was reprimanded last year for serving students expired food has wound up in the spotlight again after using supplementary material for eighth-graders that contained a sexual joke.Shanghai school

The education authority of Pudong New Area in Shanghai has ordered severe punishment for those responsible for the teaching materials used by SMIC Private School (Shanghai), and called for an overhaul of supplementary textbooks at primary and middle schools in the region.

The education bureau told the school to immediately stop using the materials, the authority said in a circular on Thursday (Jan 24). It also accused the school of chaotic management and misdeeds in the selection of supplementary materials.The reprimand was for including material in a book for youngsters that referred to female anatomy and strongly alluded to an oral sex act. It was published by Shanghai Oriental Laser Education Culture.

Parents of the eighth-graders discovered the off-colour joke, titled "Mommy's Washcloth", in a book assigned as homework for the winter vacation.Children had been asked to read the joke and leave their comments.

The school, founded in 2001 by Semiconductor Manufacturing International (Shanghai) Corp, has more than 2,900 students from 25 countries and regions. It admitted its fault in selecting the material on Thursday.The school will be severely punished for the sexually oriented joke, according to the education authority.

Mr Xiong Bingqi, deputy dean of the 21st Century Education Research Institute, said on Thursday that both the publisher and the school were at fault."That the material was able to enter the school's procurement system shows chaotic management. Private schools need to strengthen internal management to prevent such mistakes," Mr Xiong said.

He also suggested that the faculty and parents' association should be involved in the selection of supplementary learning materials at private schools. On one hand, such a move would reflect the autonomy of the school, while on the other hand it would improve the overall quality of the books the school uses, he said.On Thursday, the school strongly condemned the company and said it had punished the vice-principal and another teacher.

Last October, the school was caught up in a food safety scandal after parents found expired goods, mouldy produce and unhygienic conditions during a surprise inspection of its kitchen. That incident led to a call for stronger inspections of school canteens.

Lycored, an international wellness company at the forefront of ingredient and nutrition supplements, has launched its Lycopedia, an interactive educational hub that tells the narrative journey of lycopene and its effect on the body during different stages of life. By creating the Lycopedia, Lycored hopes it will act as a resource that showcases the health benefits of lycopene, the red-hued tomato-derived carotenoid used in food and beverage and oral supplementation.Lycopene powder
From early life, younger adult, midlife adult and older adult, the Lycopedia guides visitors through an interactive journey on lycopene, expanding on the various benefits this carotenoid provides to the body during each phase of life. Health concerns covered throughout the timeline include preeclampsia, lung health, skin health, fertility, cardiovascular health, vision health, osteoporosis and prostate health.

"We have focused a large part of more than 50 clinical studies on exploring Lycopene's different beneficial roles in our wellness at every stage of life, which resulted in us taking our Lycored Nutrient Complex range for specific indications mainstream, yet we are only scratching the surface on what our hero carotenoid is capable of for our wellbeing," said Rony Patishi-Chillim, president and CEO at Lycored. "With further research we have been able to unearth a multitude of health benefits and, as a result, we want to also make consumers and our industry aware of the significance of lycopene; not just for wellness benefits, but as a lifelong ally."

The launch of the Lycopedia showcases both the depth of research and undeniable commitment Lycored has to the wellbeing and education of creating wellness from within. Through the belief that nature holds a wealth of knowledge just waiting to be unearthed, Lycored plans to continue to introduce education tools to their community including a link to its Lycopedia on their un-branded consumer facing website, and via wide ranging partnerships including its brand ambassador network.
Men who want to reduce their risk of developing prostate cancer by altering their diet should eat tomatoes or tomato products rather than rely on lycopene supplements, suggest researchers from Ohio State University, Columbus. 502-65-8

Consumption of lycopene, an antioxidant that gives tomatoes their red colour, has been associated with reduced risk of prostate cancer in epidemiological studies. However, the new study, conducted in rats, indicates that other components found in tomatoes may also be associated.

The researchers assigned 194 male rats with prostate cancer to diets containing whole tomato powder or pure lycopene, or to a control diet. After four weeks, the rats were further divided into two groups, one with unlimited access and one with restricted access to food.

The researchers found that rats fed a diet that included whole tomato products survived longer than rats in the other groups (their risk of prostate cancer death was 26 per cent lower). Animals in the tomato-fed, energy-restricted group fared even better, showing a 32 per cent drop in risk. No benefit from lycopene alone was seen in either the energy-restricted or unrestricted groups.

“Our observations support the concept that tomato products contain components in addition to lycopene that may inhibit prostate carcinogenesis,” the researchers say. They add that many men are consuming lycopene-containing supplements in the hope that they may prevent prostate cancer or enhance the treatment of their prostate cancer. “We suggest that a focus on interventions with whole tomato products and energy balance should be a priority while clinical studies simultaneously investigate the risks and benefits of lycopene supplementation.”

The study, which lasted 14 months, is published in the Journal of the National Cancer Institute (2003;95:1578).

The authors of an accompanying editorial (ibid, p1563), Dr Peter Gann, Northwestern University, Chicago, and Dr Frederick Khachik, University of Maryland, point out that plant compounds evolved as sets of interacting compounds. This complexity limits the usefulness of seeking to identify single protective compounds.
Antioxidant Ability and Stability Studies of 3-O-Ethyl Ascorbic Acid

3-O-Ethyl-L-Ascorbic Acid, or Ethyl Ascorbic Acid is a molecule produced by modifying Ascorbic Acid, commonly known as Vitamin C. This modification is done to increase the molecule’s stability and enhance its transport through skin, as pure Vitamin C is easily degraded. In the body, the modifying group is removed and Vitamin C is restored in its natural form. Thus, Ethyl Ascorbic Acid retains the benefits of Vitamin C, such as antioxidant activity. Furthermore, it is even more potent in reducing skin darkening after UV exposure. It even has some additional effects, not observed in pure Ascorbic Acid, such as promoting nerve cell growth or reducing chemotherapy damage. Finally, the slower release also ensures that no toxic effects are observed when using this Vitamin C derivative.3-O-Ethyl-L-Ascorbic Acid

3- O -ethyl ascorbic acid may be a good whitening ingredient in cosmetics. However, before it can be successfully used in cosmetics, its biofunctionality and stability need to be comprehensively investigated. The reduction and 2,2-Diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging ability of this compound were analyzed to assess its antioxidant potential. In addition, the tyrosinase inhibitory ability was analyzed to show the whitening capacity of 3- O -ethyl ascorbic acid. Response surface methodology (RSM) was used to determine the optimal conditions for the ascorbic acid derivative in cosmetics. Based on the DPPH radical scavenging ability results, the half-inhibitory concentration (IC 50 ) value of 3- O -ethyl ascorbic acid was 0.032 g/L. It also showed a good reducing ability at 1.5 g/L concentration. Based on the tyrosinase inhibition analysis, the IC 50 value was 7.5 g/L. The opti
Beneficial effects of chrysin on the reproductive system of adult male rats



Chrysin treated male albino rats had significantly higher sperm count, fertility rate and litter size when they were permitted to mate with proven proestrous female rats[26]. These promoting effects of Chrysin was confirmed by Ciftci et al.[27]report in which testis antioxidant enzyme levels such as SOD, CAT and GSH-Px along with GSH were significantly improved following Chrysin administration. Higher sperm count and motility along with lower abnormality percentage were also recorded in their study. ...
... Higher sperm count and motility along with lower abnormality percentage were also recorded in their study. Beside antioxidant effect, both in vivo and in vitro studies have confirmed Chrysin potential for enhancing testosterone level and subsequently male sex drive[23,27]. According to the broad range of pharmacological activities of Chrysin and considering the fact that information on feeding this flavonoid to birds is lacking in literature. ...
... In the light of obtained results, Chrysin successfully improved total and forward motility, plasma membrane functionality and integrity, semen concentration and MDA level, sperm fatty acid composition, blood testosterone as well as fertility and hatchability rates. These results were in concert with previous studies in which oral administration of Chrysin to male rats significantly enhanced sperm total motility and count, blood testosterone level[27]as well as fertility and litter size in their partners. An appropriate level of dietary n-6/n-3 fatty acid ratio along with reduced MDA level (by feeding an antioxidant) resulted in increase of sperm forward motility in boar.
Chrysin (on the left) and harman (right) are organic compounds with distinctly different structures, but both are found in the passionflower species Passiflora caerulea and P. incarnata.Sesamol powder

Chrysin, also called 5,7-dihydroxyflavone, was first isolated from the wood of pine trees (Pinus spp.) in 1949 by Gösta Linstedt at the KTH Royal Institute of Technology (Stockholm). Harman (or harmane), a pyridoindole derivative, was discovered much earlier (1861) in the bark of P. incarnata and other trees by German researcher R. Rieth.

What do chrysin and harman have in common besides occurrence in trees, specifically P. incarnata? More than 500 passionflower species have been used as traditional folk remedies for anxiety and other medical conditions almost everywhere that they grow on Earth. For at least 20 years, drug researchers have sought to elucidate mechanisms by which passionflower biochemicals provide relief.

In a key 2001 study, P. incarnata extract was compared with oxazepam, an early benzodiazepine anxiolytic drug, for efficacy against generalized anxiety disorder (GAD). Shaheen Akhondzadeh and colleagues at the Tehran University of Medical Sciences and the Institute of Medicinal Plants (both in Tehran, Iran) treated 36 patients diagnosed with GAD with P. incarnata extract, oxazepam, or placebo in a 4-week trial.

The extract and the drug gave equally positive results. Oxazepam acted more rapidly, but it also impaired the subjects’ job performance whereas the extract did not. In the time since this report was issued, however, there is no record of US Food and Drug Administration filings for chrysin, harman, or passionflower extracts.

This discussion of anxiety remedies reminds us that today is the beginning of Mental Health Awareness Week.
N-(1-Phenylpyrazol-3-yl)-N-[1-(2-phenylethyl)-4-piperidyl]propanamide


The oxalate salts and free bases of fentanyl and N-[1-(2-phenylethyl)-4-piperidyl]-N-(1-phenyl-4-pyrazolyl)propanamide, a new lead compound for long-acting analgesia, have been characterized by (1)H- and (13)C-NMR spectroscopy. The crystal structure of the hydrochloride of N-[1-(2-phenylethyl)-4-piperidyl]-N-(1-phenyl-4-pyrazolyl)propanamide monohydrate has been determined. N-Phenyl-N-(4-piperidinyl)propanamide HCL
Two centrosymmetrically related cations, joined through C(phenyl)-H em leader pi contacts, encapsulate a large void that contains pairs of anions and bridged water molecules into a zero-dimensional (0D) supramolecular motif. The cations are linked to this framework via N(+)H em leader Cl(-) contacts. GIAO/B3LYP calculations have been carried out to compare the experimental (13)C chemical shifts with the absolute shieldings thus calculated. The protonation of both molecules takes place on the piperidine ring (axial protonation), as has been verified both in the solid state (X-ray) and in solution (NMR).
372,000 children in China are now enrolled in an international style of education and 66% of these children are Chinese nationals attending international Chinese-owned private schools in the country.Educational Leadership training china

Latest market trends from ISC Research on international education in China include data from this school year (2018-2019). They show that the international private schools market in China has grown substantially due to an increasing demand from Chinese parents for an international, bilingual approach to learning for their children.

Five years ago, there were 629 international schools in China, many of which were schools for the children of foreign nationals that had very limited access to Chinese children. Today, there are 857 international schools in China and 563 of them are international Chinese-owned private schools. Over that same period, there has been a 63.6% increase in student enrolment, with 245,500 students now enrolled in the international Chinese private schools.

These schools are particularly successful because, during the compulsory years of education, the Chinese curriculum can be integrated with elements of international teaching and learning, including some learning in the language of English. Such a bicultural educational approach is what a growing number of Chinese families want; one that retains local culture and history, while introducing international elements that provide the skills necessary to prepare children for global higher education and careers.

There are several factors that have prompted this market change including an increase in education expenditure by more families as a result of a growth in prosperity in the country; the impact of China's two-child policy which is now seeing an effect within Early Years education; amendments that have been made to education regulations in recent years which now provide clearer guidelines and more opportunities for foreign schools to engage with the private education sector; and an increasing awareness by Chinese parents of locally accessible private international education opportunities.

Foreign education brands are driving the success of many of the international Chinese private schools. During the past five years, 31 independent school brands, mostly from the UK, but also from the US, have established agreements with Chinese schools and investors in order to deliver teaching expertise and an international style of education. Such partnerships are appealing to wealthier Chinese families who value the educational heritage, reputation, brand prestige, and opportunities that the UK and US schools are bringing to China.

International schooling options accessible to local families are available in many of China's Tier 1 cities. Although Shanghai and Beijing dominate, there are now 55 international schools in Shenzhen, 47 in Guangzhou, 25 in Chengdu, and several in a growing number of cities throughout China.

ISC Research is aware of at least 48 new international schools due to open in China in the next few years, many of which will be the international Chinese private schools partnering with foreign independent school brands.

ISC Research supplies primary-source intelligence and data - much of it collected by its own field-based researchers - on the English-medium K-12 international schools market in key countries most appropriate for international school development, including China. The ISC China Market Intelligence Report supports schools, investors and developers with detailed data and market intelligence to support due diligence and strategic planning for new school developments and agreements. The data and intelligence in this report is gathered directly from schools, government bodies and reputable associations in China to produce detailed demand analysis of this developing market.
Off the court, the sixth-grader from Wuxi, in eastern China’s Jiangsu province, speaks quietly and gently. But when it’s game time, she’s laser-focused as she chases the ball, moving energetically across the court.Children tennis in Shanghai

Despite an overall trend of declining health and athleticism among Chinese children, a growing number of young people are taking up tennis — a sport invented in the U.K. in 1873 that barely existed in China less than two decades ago.

Like many others, Ni began playing tennis in 2011, when China’s former world No. 2 women’s tennis player Li Na became the first from Asia to win the Grand Slam championship title at the French Open. Li’s success led to a domestic tennis fever, and that same year, Ni’s father and coach, Xi Zhiye, began training his then-5-year-old daughter.“There was a surge in the number of Chinese teenagers starting to learn tennis that year — some of the parents thought the sport could be a possible future for their children,” said Xi, who quit his job in securities trading two years ago to focus on his daughter’s tennis training.

In her age group, Ni is a top player: Last year, she won third place in the national Zheng Jie Cup teen tennis tournament. The 11-year-old is a short-distance runner and a soccer player on the school teams, but it’s her tennis ability cultivated over six years of intensive training that has won her the most medals.

“I like playing tennis. It helps me relax after school,” Ni told Sixth Tone. “I’m the only one at my school who plays tennis, but I don’t feel lonely — I make friends at different tournaments, and they’re all excellent tennis players.”

The number of tennis players registered at Shanghai’s 16 government-run children’s sports clubs has increased tenfold since 2007, from 100 to 1,075 today, according to the city’s tennis association. A decade ago, only five of the 16 district clubs offered tennis, but now each has a team, said Xue Lei, vice secretary-general of the association. Tennis is also being offered at schools alongside other sports as part of a wider push by the Chinese government to encourage children to stay active.

Xue attributes the increased interest in youth tennis to the sport’s growing profile in China. In 1998, the international tennis tournament Heineken Open came to Shanghai, making it the first world-class tennis competition in the country. The Tennis Masters Cup and ATP World Tour Masters 1000 tournaments followed a few years later. Earlier this month, the Shanghai Masters entered its ninth year, drawing top international players like men’s singles champion Roger Federer.

“Many young parents today grew up watching these tennis games or following a certain star tennis player,” said Xue. “Motivated by their own interest in the sport, they started bringing their children to the court.”

This is certainly true for Ni, whose father began playing tennis as a hobby in the late 1990s and remains a loyal fan of Federer. Xi couldn’t wait to start teaching his daughter the sport when she turned 5 — considered the minimum age for children to start tennis training.school’s permission — and takes her to the court for her two-hour tennis practice. After dinner, she spends an hour on homework and goes to bed by 9:30 p.m.

Height is one barrier to playing tennis professionally. Top female tennis players must be relatively tall to reach the ball, but not so tall that their height slows them down. Ni undergoes bone age assessments every year to track her skeletal development, and current estimates suggest the 155-centimeter-tall girl could grow to between 172 centimeters and 175 centimeters — tall enough to pursue a professional tennis career. (By comparison, China’s top female tennis player, Li, is 172 centimeters tall.)

Ni’s father believes the real challenges lie ahead, when his daughter may be forced to choose between athletics and academics. While Xi believes university studies are a must, he doesn’t want her tennis training to go to waste. “In the U.S., there’s no contradiction between sports and academic studies, but in China, it’s the reality,” he explained. “Without appropriate academic learning, I’m afraid Ni would fall behind in terms of general knowledge and communication skills.”
Concordia’s Middle School works in partnership with parents to create a school community that is supportive and responsive to student needs. Children between the ages of 10 and 14 are unique in intellectual, social, emotional, and physical growth. Recognizing that these children are also strikingly different from each other, the middle school is designed to meet the needs of a child as well as an adolescent during the transition from the elementary to high school. Through a caring and secure environment, the middle school program ensures that all students experience challenge and success.International middle school

At Concordia our Middle School program is based upon the developmental needs of the young adolescent with the following goals:

Mastering basic skills within an interdisciplinary context.
Acquiring a fundamental body or knowledge and the critical thinking skills necessary for its interpretation and application.
Developing and maintaining a positive self-image.
Accepting increased social, personal and academic responsibilities.
Exploring a diversity of curricular and extracurricular activities.
Developing an increased awareness of individual differences and respect for others.
Participating responsibly in the school community.
On Sunday, tens of thousands of professional and amateur runners will hit the streets of Britain's capital for the London Marathon, one of the world’s most prestigious long-distance running races.But while any doctor can tell us the benefits of exercise, there are some experts who believe that marathon-length runs - just over 26 miles - are too extreme for the average runner, and can be dangerous.To get more marathon length, you can visit shine news official website.

Virgin, which sponsors the London Marathon, says that “running is good for the heart” and stresses that more than one million people have safely completed the marathon in its 38-year history, but acknowledges that there have still been “several fatalities from serious heart disease in runners apparently unaware that they had a problem”.

Since the first event in 1981, a total of 12 participants have died, the most recent of whom was former Masterchef semi-finalist Matt Campbell.Campbell collapsed and died during last year’s marathon, when temperatures hit an all-time high for the event.This news was followed just a few months later by reports that two men had died after collapsing at the finish line of the Cardiff Half Marathon in October 2018.

The competitors, aged 25 and 32, “went into cardiac arrest after crossing the finishing line within three minutes of each other, at about 12.25pm”, reports the BBC.Given the number of people who take part in such races each year, just how dangerous is long-distance running?

How safe are marathons?
The BBC reports that most of the casualties that occur during a race concern minor injuries, like pulled muscles, sprains and strains. These tend to heal quickly and on their own.

The broadcaster adds that dehydration is the biggest problem that marathon runners have to overcome. “In a hard race on a hot and humid day, up to four litres of fluid can be lost through sweating and exhalation,” it says. “It is important for runners to keep well hydrated.”

But an increasing number of studies are now linking long-distance running with sudden heart conditions and issues that were undetected previously, even if there is no family history of similar health issues.

In a study published in December in the journal Circulation, researchers in Spain revealed that full marathons may put significant strain on the heart. In order to do this, the team measured substances that can signal stress and found higher levels in runners who covered the classic 26.2 mile (42.2 kilometres) marathon distance compared with those who raced shorter distances such as a half-marathon or 10K, Health24 reports.

A study presented to the American College of Cardiology in 2009 found that the risk of sudden death during a marathon is 0.8 per 100,000 people. By comparison, the report found that triathlons – which ask users to complete three sequential endurance races in swimming, running and cycling – have a significantly higher risk of sudden death at 1.5 in 100,000. To put this into perspective, the risk of dying in childbirth in the UK in 2012 was 8.6 in 100,000 births, according to The Daily Telegraph.

How does it affect the heart?
A number of independent studies have found that marathons appear to cause damage to the heart in the short term, but researchers are unsure whether the effects are lasting. Some note that there are cardiovascular advantages to regular running. “Being fit is protective,” Dr James Freeman, a fellow in cardiovascular medicine at Stanford University School of Medicine told The New York Times. Professor Sanjay Sharma, medical director for the London Marathon, told the BBC that most people who have died during the London marathon have had previous heart conditions or heart disease.
In 2013, President Xi Jinping proposed that China would create a “Silk Road Economic Belt” across Central Asia and Europe and a “21st Century Maritime Silk Road” running through the South China Sea and the Indian Ocean, on to the Middle East and Europe — programs meant to revive ancient trade routes and reinforce existing ones. Beijing quickly wove these two visions together and dubbed them the Belt and Road Initiative (BRI).To get more belt and road, you can visit shine news official website.

While seemingly aimed at regional economic corridors, the BRI is in fact global and motivated by economic and strategic interests. A successful BRI would allow China to more efficiently utilize excess savings and construction capacity, expand trade, consolidate economic and diplomatic relations with participating countries, and diversify China’s import of energy and other resources through economic corridors that circumvent routes that are controlled by the U.S. and its allies.

The initiative is generally popular in the developing world, where almost all countries face infrastructure deficiencies and a shortage of resources to overcome them. Through large amounts of loans to participating countries to construct infrastructure in various sectors, the BRI can potentially bring significant benefits to these countries by filling their infrastructure gaps and boosting economic growth.

While popular with developing countries, the initiative has received various criticisms from advanced industrial economies: that the program lacks transparency and serves to facilitate China’s export of its authoritarian model; that the commercial loan terms are bringing on a new round of debt crises in the developing world; and that the projects have inadequate environmental and social safeguards.

This paper examines the implementation of BRI infrastructure projects in Africa in light of available information and concludes that African experiences with the BRI are quite heterogeneous. Some of the major borrowers have debt sustainability problems, while others have integrated the loans from China into sound overall macroeconomic programs. Some of the major borrowers are authoritarian countries with poor records of human rights, but other major participants are among the more democratic countries of Africa. It is hard to make simple generalizations about BRI in Africa. For this reason, it would be wise for Western countries to tone down their rhetoric on BRI, as many of the projects will probably work out well. It would help if Western countries provided more support to the International Monetary Fund to help countries manage their borrowing and to the World Bank to provide more infrastructure financing that increased options for the developing countries of Africa.
Hot Sale CAS 82640-04-8 Raloxifene HCl Powder with Best Price



What is Raloxifene HCL ?

Raloxifene HCL is an oral selective estrogen receptor modulator (SERM) that has estrogenic actions on bone and anti-estrogenic actions on the uterus and breast. Raloxifene HCL is used in the prevention of osteoporosis in postmenopausal women.Raloxifene powder
Fuction of Raloxifene HCL
Raloxifene HCL is used to prevent and treat osteoporosis (condition in which the bones become thin and weak and break easily) in women who have undergone menopause (change of life; end of menstrual periods).
Raloxifene HCL is also used to decrease the risk of developing invasive breast cancer (breast cancer that has spread outside of the milk ducts or lobules into the surrounding breast tissue) in women who are at high risk of developing this type of cancer or who have osteoporosis.
Raloxifene HCL cannot be used to treat invasive breast cancer or to prevent invasive breast cancer from coming back in women who have already had the condition.

Raloxifene HCL also cannot be used to decrease the risk of developing non-invasive breast cancer. Raloxifene HCL is in a class of medications called selective estrogen receptor modulators (SERMs). Raloxifene HCL prevents and treats osteoporosis by mimicking the effects of estrogen (a female hormone produced by the body) to increase the density (thickness) of bone.
Raloxifene HCL decreases the risk of developing invasive breast cancer by blocking the effects of estrogen on breast tissue.
Raloxifene HCL may stop the development of tumors that need estrogen to grow.
Application of Raloxifene HCL

Raloxifene Hydrochloride is an active pharmaceutical ingredient used to prevent osteoporosis in postmenopausal women and to reduce the risk of invasive breast cancer in postmenopausal women with osteoporosis and in postmenopausal women at high risk for invasive breast cancer.
High Purity and High-Speed Delivery Anastrozole Acetate
Arimidex, Cas No: 120511-73-1, Anastrozole Acetate, Anastrol
Arimidex Description:
Ana strozoles
Arimidex Alias: Arimidex
Arimidex CAS No: 120511-73-1
Arimidex MF: C17H19N5
Arimidex MW: 293.37
Arimidex Purity: 98%min
Arimidex Appearance: White crystalline powder.
Arimidex Usage: An aromatase inhibitor. Used as an antineoplastic raw materials.
Potent selective triazole aromatase inhibitors, can inhibit the cytochrome P-450 aromatase enzyme which depends blocking the biosynthesis of estrogen, and estrogen to stimulate breast cancer cell growth factors. Treatment of breast cancer, especially for those with hormone relapse after adjuvant therapy after menopause for women with advanced breast cancer.

Arimidex Applications:
The drug is appropriately used when using substantial amounts of aromatizing steroids, or when one is prone to gynecomastia and using moderate amounts of such steroids. Arimidex does not have the side effects of aminoglutethimide (Cytadren) and can achieve a high degree of estrogen blockade, much moreso than Cytadren. It is possible to reduce estrogen too much with Arimidex, and for this reason blood tests, or less preferably salivary tests, should be taken after the first week of use to determine if the dosing is correct.
Appearance: Off-white crystalline powder
Packing: Aluminum foil bag+cardboard box, 100 grams/bag; 500 grams/bag; 1kg/bag
Used: Raw material powder
Min. Order quantity: 5g
Terms of payment: T/T, Western Union, Money Gram
Way of shipping: EMS, DHL, FedEx, UPS

Product info.

No Side Effect Arimidex Steroid Healthly Anti Estrogen Hormone

Anastrozole Arimidex is a non-steroidal drug which is used to treat breast cancer. It has been thoroughly studied in women with breast cancer between the 5th-8th decades of life. There are some breast cancers which are dependent on estrogen for their growth. Arimidex acts by suppressing the levels of estrogen in the body and thus reduces the growth of breast cancer. The drug is first line treatment in post menopausal women with early breast cancer or in those with advanced breast cancer despite taking tamoxifen. Arimidex is often combined with other drugs to treat breast cancer in post menopausal women. The drug has been used to treat early or advanced breast cancer in women all cultures and races.β-agonist Powder
The trial suggested that is the preferred medical therapy for Postmenopausal women with localized breast cancer that is estrogen receptor (ER) positive.
Three azole potent selective aromatase inhibitors, which inhibit rely on aromatase cytochrome P -450 to block estrogen biosynthesis, and the main factors of estrogen to stimulate breast cancer cell growth. It can treat breast cancer, especially suitable for those who relapse after treatment with hormone auxiliary advanced breast cancer after menopause women.
The chemical name for Timolol maleate is (S)-1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol (Z)-2-butenedioate (1:1) salt. It possesses an asymmetric carbon atom in its structure and is provided as the levo isomer. Its molecular formula is C13H24N4O3S•C4H4O4and its structural formula is:

Timolol maleate has a molecular weight of 432.50. It is a white, odorless, crystalline powder which is soluble in water, methanol, and alcohol.Timolol maleate is supplied as tablets containing 5 mg, 10 mg and 20 mg Timolol maleate for oral administration. Inactive ingredients are: colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, microcrystalline cellulose, pregelatinized maize starch, sodium lauryl sulfate.Timolol

CLINICAL PHARMACOLOGY
Timolol maleate is a beta1 and beta2 (nonselective) adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic activity.

Pharmacodynamics
Clinical pharmacology studies have confirmed the beta-adrenergic blocking activity as shown by (1) changes in resting heart rate and response of heart rate to changes in posture; (2) inhibition of isoproterenol-induced tachycardia; (3) alteration of the response to the Valsalva maneuver and amyl nitrite administration; and (4) reduction of heart rate and blood pressure changes on exercise.

Timolol decreases the positive chronotropic, positive inotropic, bronchodilator, and vasodilator responses caused by beta-adrenergic receptor agonists. The magnitude of this decreased response is proportional to the existing sympathetic tone and the concentration of Timolol at receptor sites.In normal volunteers, the reduction in heart rate response to a standard exercise was dose dependent over the test range of 0.5 to 20 mg, with a peak reduction at 2 hours of approximately 30% at higher doses.

Beta-adrenergic receptor blockade reduces cardiac output in both healthy subjects and patients with heart disease. In patients with severe impairment of myocardial function beta-adrenergic receptor blockade may inhibit the stimulatory effect of the sympathetic nervous system necessary to maintain adequate cardiac function.

Beta-adrenergic receptor blockade in the bronchi and bronchioles results in increased airway resistance from unopposed parasympathetic activity. Such an effect in patients with asthma or other bronchospastic conditions is potentially dangerous.

Clinical studies indicate that Timolol maleate at a dosage of 20 to 60 mg/day reduces blood pressure without causing postural hypotension in most patients with essential hypertension. Administration of Timolol to patients with hypertension results initially in a decrease in cardiac output, little immediate change in blood pressure, and an increase in calculated peripheral resistance. With continued administration of Timolol, blood pressure decreases within a few days, cardiac output usually remains reduced, and peripheral resistance falls toward pretreatment levels. Plasma volume may decrease or remain unchanged during therapy with Timolol. In the majority of patients with hypertension Timolol also decreases plasma renin activity. Dosage adjustment to achieve optimal antihypertensive effect may require a few weeks. When therapy with Timolol is discontinued, the blood pressure tends to return to pretreatment levels gradually. In most patients the antihypertensive activity of Timolol is maintained with long-term therapy and is well tolerated.

The mechanism of the antihypertensive effects of beta-adrenergic receptor blocking agents is not established at this time. Possible mechanisms of action include reduction in cardiac output, reduction in plasma renin activity, and a central nervous system sympatholytic action.

A Norwegian multi-center, double-blind study, which included patients 20 to 75 years of age, compared the effects of Timolol maleate with placebo in 1,884 patients who had survived the acute phase of a myocardial infarction. Patients with systolic blood pressure below 100 mm Hg, sick sinus syndrome and contraindications to beta-blockers, including uncontrolled heart failure, second- or third-degree AV block and bradycardia (< 50 beats per minute), were excluded from the multi-center trial. Therapy with Timolol, begun 7 to 28 days following infarction, was shown to reduce overall mortality; this was primarily attributable to a reduction in cardiovascular mortality. Timolol significantly reduced the incidence of sudden deaths (deaths occurring without symptoms or within 24 hours of the onset of symptoms), including those occurring within one hour, and particularly instantaneous deaths (those occurring without preceding symptoms). The protective effect of Timolol was consistent regardless of age, sex or site of infarction. The effect was clearest in patients with a first infarction who were considered at a high risk of dying, defined as those with one or more of the following characteristics during the acute phase: transient left ventricular failure, cardiomegaly, newly appearing atrial fibrillation or flutter, systolic hypotension, or SGOT (ASAT) levels greater than four times the upper limit of normal. Therapy with Timolol also reduced the incidence of nonfatal reinfarction. The mechanism of the protective effect of Timolol is unknown.

Timolol was studied for the prophylactic treatment of migraine headache in placebo-controlled clinical trials involving 400 patients, mostly women between the ages of 18 and 66 years. Common migraine was the most frequent diagnosis. All patients had at least two headaches per month at baseline. Approximately 50 percent of patients who received Timolol had a reduction in the frequency of migraine headache of at least 50 percent, compared to a similar decrease in frequency in 30 percent of patients receiving placebo. The most common cardiovascular adverse effect was bradycardia (5.
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