Text description provided by the architects. Dayuan, the founder of the
school, was once one of the best middle school linguistics teachers,
later he became a businessman due to peculiar encounters. However, there
is always a dream about education in his heart. For the olive tree in
his dreams, he finally set off after many years of preparation.
international school in hangzhou
After several discussions and inevitable collisions of ideas, the architects determined the overall layout:
The buildings and the sports areas take one half of the site each.
Although the east-west oriented track and the dormitories are not
common, the overall structure is compact, well responding to the
high-speed train line, the highway entrance on the south and the main
urban boulevard on the west.
All the art and experience spaces are located on the ground floor;
Public spaces such as roof gardens, vegetable gardens, science museum
are on the top floor; Classrooms and offices are located on the floors
in-between.
The ideal school buildings in Dayuan’s mind should have conversations
between western and eastern cultures, and inherit the spirit from both
the old times and new days. Below are the architects’ considerations and
responses:
Courtyard is a basic spatial element that is common in all kinds of cultures in ancient and modern China and abroad.
Pitched roof is a basic form in the culture at all times and in all over
the world.Chinese tradition is to enter the building from the eave
side; whereas the western world from the gable wall.
Arch is an important element of Western classical architecture; to place
buildings along the south-north axis and form a layered courtyard is a
common method for classical Chinese architecture.The red brick façade is
a common practice in Western architecture; whilethe white wall is
widely used in classical architecture in the Jiangnan area.
The primary school has two layers of courtyards with the theme of
nature; three olive trees from the Mediterranean are planted in the high
school courtyard with red brick walls on four sides; white walls with
light wooden colored railing and roof structure are used in middle
school courtyard; there is a pool of water in between middle school and
high school, with eight types of aquatic plants native to Jiangnan.
Olive tree represents Global vision, “Shuibaxian” (eight types of
aquatic plants) reflects Chinese feeing and native sentiment.
There is a river in the east of the site, so a bridge that meets the
functions is needed. The international school curriculum attends to both
Chinese and Western cultures. A symbolic meaning of ‘connection’ is
applied to a functional bridge located on the east side entrance. The
complex shape of the continuous integration of the slab of the entrance
arch bridge and roof allows the digital design and fabrication to take
their advantages.
The perforated pattern of the red brick wall in east façade and the
color composition pattern of the west façade of the dormitory source
from the same part of the famous Chinese painting, Dwelling in the
Fuchun Mountains. Byintegrating digital technology, there is no
difficulty to abstract the artistic masterpiece into architectural
decorative elements.
The core value of this design is to involve the process and method of
architectural design in the basic education process, so as to let the
kids who study in the school have the opportunity to learn and
experience the different form transition, by combining art and
technology.
One of the things I appreciate about you guys is that you set me
straight when I have crazy ideas. Yes, maybe in retrospect moving to the
Lufthansa First Class Terminal wasn’t the brightest idea ever, though
that’s why I run these ideas past you guys before “executing.”
living in tianjin
I have another idea, but this time I’m fairly certain it’s genius,
though I’ll run it past you guys anyway. I’ve decided to move to
Tianjin, China. I know what you’re thinking: what a brilliant idea, go
for it! Why Tianjin, you ask?
Well, the St. Regis Tianjin just opened a few months ago, and the rates
are rather good, about ~$140USD/night.My plan is to move there and live
on the American Express Fine Hotels & Resorts rate, which includes
complimentary daily breakfast, guaranteed 4PM check-out, a room upgrade,
and a $100 food and beverage credit per stay. Add that to my Starwood
Platinum benefits, and I’ll be living the high life for pennies on the
dollar.
The only downside is that the food and beverage credit is per stay as
opposed to per night, so I guess I’ll have to stay at the Westin every
other night. Or maybe I need to move there with a friend and we need to
have alternating reservations every other night.
The International School of Tianjin (IST ) is an International
Baccalaureate (IB) World School, and the only international school in
Tianjin authorized to teach all three IB Programs (Primary Years, Middle
Years, and Diploma). IST provides an education of distinction to young
global citizens while serving the needs of our communities. The schools
comprehensive and coherent written curriculum is based upon the highest
academic standards. As a school we use the mission of the IB and the
philosophy of IST to guide our deliberations and actions, and to ensure
that our children develop the attitudes and dispositions of true
internationalists prepared for the challenges and wonders of life beyond
our school.
international school in Tianjin
An extensive extracurricular activities program is available to
students, including the ACAMIS and ISAC inter-school sports leagues,
Model United Nations (MUN), Global Issues Network (GIN), Choir and
Orchestra, Roots and Shoots, and Student Council.
School Facilities World class, purpose-built school campus, situated on
7.2 hectares of park-like grounds. Including a natural grass football
pitch surrounded by 400m running track. An indoor (double-sized)
gymnasium with floor-to-ceiling climbing wall. 95 classrooms (equipped
with computers, digital projectors and whiteboards), 5 science
laboratories, 4 main computer laboratories. Library with extensive
collection including a large selection of foreign language books in the
following languages: Chinese, Korean, French, German, Danish, Japanese,
Spanish, Hindi, Dutch, and Italian.) Dedicated early childhood center
with indoor and outdoor play areas. A primary school building and a
separate new secondary school building, including a 520-seat theater,
black box and extensive music and art suites and design and technology
classrooms.
On May 9, the awards ceremony for the 2019 Tianjin Recycling Educational
Challenge (TReC) was held at the Himalaya Tianta. This was the TreC
program’s 4th year, continuing on its tradition as an educational
initiative developed by TJenvironcom and organized by the Tianjin
Chapter of AmCham China, where Tianjin's premier international schools
participate in a week of recycling and environmental activities.
Activities include a recyclables collection drive, as well as an art
competition where artwork is composed from recycled materials.
Tianjin international school
This year saw participation from Tianjin International School,
Wellington Tianjin, Tianjin Yinghua International School (Wuqing and
Dongli Campuses), and TEDA International School. Caterpillar Tianjin
Ltd., with Anisa Cosmetics sponsoring materials for use in the creation
of artwork. Prize sponsors included Ocean Park and the Cambridge Mask
Company. Himalaya Tianta Apartments was the venue and awards sponsor
Approx. 1300 kgs of recyclable materials were collected during the week,
a year-on-year gain of 69%, and almost 50 works of art were created
from materials donated by CAT and Anisa.
Additionally, during his visit to Tianjin on May 7, US Ambassador to
China Terry Branstad viewed some of the artwork, and heard from some of
the participating students about their thoughts on the environment and
the TreC project.
Representatives from the US Embassy Environmental Section, local
artists, and representatives from NGOs including Conservation
International and the APEC Green Supply Chain Center served as judges in
the art segment. The awards ceremony was hosted by TJenvironcom founder
Alex Scilla.The TReC-TECC Total [TTT], a tally of the results to date
between TReC and it’s sister program TECC (The Tianjin Environmental CSR
Challenge) is now ranking in at a recovery total of 3077 kgs of
secondary resources, reduced energy usage of over of 30000 kwh, and
water savings of over 200 tons.
A school that was reprimanded last year for serving students expired
food has wound up in the spotlight again after using supplementary
material for eighth-graders that contained a sexual joke.
Shanghai school
The education authority of Pudong New Area in Shanghai has ordered
severe punishment for those responsible for the teaching materials used
by SMIC Private School (Shanghai), and called for an overhaul of
supplementary textbooks at primary and middle schools in the region.
The education bureau told the school to immediately stop using the
materials, the authority said in a circular on Thursday (Jan 24). It
also accused the school of chaotic management and misdeeds in the
selection of supplementary materials.The reprimand was for including
material in a book for youngsters that referred to female anatomy and
strongly alluded to an oral sex act. It was published by Shanghai
Oriental Laser Education Culture.
Parents of the eighth-graders discovered the off-colour joke, titled
"Mommy's Washcloth", in a book assigned as homework for the winter
vacation.Children had been asked to read the joke and leave their
comments.
The school, founded in 2001 by Semiconductor Manufacturing International
(Shanghai) Corp, has more than 2,900 students from 25 countries and
regions. It admitted its fault in selecting the material on Thursday.The
school will be severely punished for the sexually oriented joke,
according to the education authority.
Mr Xiong Bingqi, deputy dean of the 21st Century Education Research
Institute, said on Thursday that both the publisher and the school were
at fault."That the material was able to enter the school's procurement
system shows chaotic management. Private schools need to strengthen
internal management to prevent such mistakes," Mr Xiong said.
He also suggested that the faculty and parents' association should be
involved in the selection of supplementary learning materials at private
schools. On one hand, such a move would reflect the autonomy of the
school, while on the other hand it would improve the overall quality of
the books the school uses, he said.On Thursday, the school strongly
condemned the company and said it had punished the vice-principal and
another teacher.
Last October, the school was caught up in a food safety scandal after
parents found expired goods, mouldy produce and unhygienic conditions
during a surprise inspection of its kitchen. That incident led to a call
for stronger inspections of school canteens.
Lycored, an international wellness company at the forefront of
ingredient and nutrition supplements, has launched its Lycopedia, an
interactive educational hub that tells the narrative journey of lycopene
and its effect on the body during different stages of life. By creating
the Lycopedia, Lycored hopes it will act as a resource that showcases
the health benefits of lycopene, the red-hued tomato-derived carotenoid
used in food and beverage and oral supplementation.
Lycopene powder
From early life, younger adult, midlife adult and older adult, the
Lycopedia guides visitors through an interactive journey on lycopene,
expanding on the various benefits this carotenoid provides to the body
during each phase of life. Health concerns covered throughout the
timeline include preeclampsia, lung health, skin health, fertility,
cardiovascular health, vision health, osteoporosis and prostate health.
"We have focused a large part of more than 50 clinical studies on
exploring Lycopene's different beneficial roles in our wellness at every
stage of life, which resulted in us taking our Lycored Nutrient Complex
range for specific indications mainstream, yet we are only scratching
the surface on what our hero carotenoid is capable of for our
wellbeing," said Rony Patishi-Chillim, president and CEO at Lycored.
"With further research we have been able to unearth a multitude of
health benefits and, as a result, we want to also make consumers and our
industry aware of the significance of lycopene; not just for wellness
benefits, but as a lifelong ally."
The launch of the Lycopedia showcases both the depth of research and
undeniable commitment Lycored has to the wellbeing and education of
creating wellness from within. Through the belief that nature holds a
wealth of knowledge just waiting to be unearthed, Lycored plans to
continue to introduce education tools to their community including a
link to its Lycopedia on their un-branded consumer facing website, and
via wide ranging partnerships including its brand ambassador network.
Men who want to reduce their risk of developing prostate cancer by
altering their diet should eat tomatoes or tomato products rather than
rely on lycopene supplements, suggest researchers from Ohio State
University, Columbus.
502-65-8
Consumption of lycopene, an antioxidant that gives tomatoes their
red colour, has been associated with reduced risk of prostate cancer in
epidemiological studies. However, the new study, conducted in rats,
indicates that other components found in tomatoes may also be
associated.
The researchers assigned 194 male rats with prostate cancer to diets
containing whole tomato powder or pure lycopene, or to a control diet.
After four weeks, the rats were further divided into two groups, one
with unlimited access and one with restricted access to food.
The researchers found that rats fed a diet that included whole
tomato products survived longer than rats in the other groups (their
risk of prostate cancer death was 26 per cent lower). Animals in the
tomato-fed, energy-restricted group fared even better, showing a 32 per
cent drop in risk. No benefit from lycopene alone was seen in either the
energy-restricted or unrestricted groups.
“Our observations support the concept that tomato products contain
components in addition to lycopene that may inhibit prostate
carcinogenesis,” the researchers say. They add that many men are
consuming lycopene-containing supplements in the hope that they may
prevent prostate cancer or enhance the treatment of their prostate
cancer. “We suggest that a focus on interventions with whole tomato
products and energy balance should be a priority while clinical studies
simultaneously investigate the risks and benefits of lycopene
supplementation.”
The study, which lasted 14 months, is published in the Journal of the National Cancer Institute (2003;95:1578).
The authors of an accompanying editorial (ibid, p1563), Dr Peter
Gann, Northwestern University, Chicago, and Dr Frederick Khachik,
University of Maryland, point out that plant compounds evolved as sets
of interacting compounds. This complexity limits the usefulness of
seeking to identify single protective compounds.
Antioxidant Ability and Stability Studies of 3-O-Ethyl Ascorbic Acid
3-O-Ethyl-L-Ascorbic Acid, or Ethyl Ascorbic Acid is a molecule
produced by modifying Ascorbic Acid, commonly known as Vitamin C. This
modification is done to increase the molecule’s stability and enhance
its transport through skin, as pure Vitamin C is easily degraded. In the
body, the modifying group is removed and Vitamin C is restored in its
natural form. Thus, Ethyl Ascorbic Acid retains the benefits of Vitamin
C, such as antioxidant activity. Furthermore, it is even more potent in
reducing skin darkening after UV exposure. It even has some additional
effects, not observed in pure Ascorbic Acid, such as promoting nerve
cell growth or reducing chemotherapy damage. Finally, the slower release
also ensures that no toxic effects are observed when using this Vitamin
C derivative.
3-O-Ethyl-L-Ascorbic Acid
3- O -ethyl ascorbic acid may be a good whitening ingredient in
cosmetics. However, before it can be successfully used in cosmetics, its
biofunctionality and stability need to be comprehensively investigated.
The reduction and 2,2-Diphenyl-1-picrylhydrazyl (DPPH) free radical
scavenging ability of this compound were analyzed to assess its
antioxidant potential. In addition, the tyrosinase inhibitory ability
was analyzed to show the whitening capacity of 3- O -ethyl ascorbic
acid. Response surface methodology (RSM) was used to determine the
optimal conditions for the ascorbic acid derivative in cosmetics. Based
on the DPPH radical scavenging ability results, the half-inhibitory
concentration (IC 50 ) value of 3- O -ethyl ascorbic acid was 0.032 g/L.
It also showed a good reducing ability at 1.5 g/L concentration. Based
on the tyrosinase inhibition analysis, the IC 50 value was 7.5 g/L. The
opti
Beneficial effects of chrysin on the reproductive system of adult male rats
Chrysin
treated male albino rats had significantly higher sperm count,
fertility rate and litter size when they were permitted to mate with
proven proestrous female rats[26]. These promoting effects of Chrysin
was confirmed by Ciftci et al.[27]report in which testis antioxidant
enzyme levels such as SOD, CAT and GSH-Px along with GSH were
significantly improved following Chrysin administration. Higher sperm
count and motility along with lower abnormality percentage were also
recorded in their study. ...
... Higher sperm count and motility along with lower abnormality
percentage were also recorded in their study. Beside antioxidant effect,
both in vivo and in vitro studies have confirmed Chrysin potential for
enhancing testosterone level and subsequently male sex drive[23,27].
According to the broad range of pharmacological activities of Chrysin
and considering the fact that information on feeding this flavonoid to
birds is lacking in literature. ...
... In the light of obtained results, Chrysin successfully improved
total and forward motility, plasma membrane functionality and integrity,
semen concentration and MDA level, sperm fatty acid composition, blood
testosterone as well as fertility and hatchability rates. These results
were in concert with previous studies in which oral administration of
Chrysin to male rats significantly enhanced sperm total motility and
count, blood testosterone level[27]as well as fertility and litter size
in their partners. An appropriate level of dietary n-6/n-3 fatty acid
ratio along with reduced MDA level (by feeding an antioxidant) resulted
in increase of sperm forward motility in boar.
Chrysin (on the left) and harman (right) are organic compounds with
distinctly different structures, but both are found in the passionflower
species Passiflora caerulea and P. incarnata.
Sesamol powder
Chrysin, also called 5,7-dihydroxyflavone, was first isolated from
the wood of pine trees (Pinus spp.) in 1949 by Gösta Linstedt at the KTH
Royal Institute of Technology (Stockholm). Harman (or harmane), a
pyridoindole derivative, was discovered much earlier (1861) in the bark
of P. incarnata and other trees by German researcher R. Rieth.
What do chrysin and harman have in common besides occurrence in
trees, specifically P. incarnata? More than 500 passionflower species
have been used as traditional folk remedies for anxiety and other
medical conditions almost everywhere that they grow on Earth. For at
least 20 years, drug researchers have sought to elucidate mechanisms by
which passionflower biochemicals provide relief.
In a key 2001 study, P. incarnata extract was compared with
oxazepam, an early benzodiazepine anxiolytic drug, for efficacy against
generalized anxiety disorder (GAD). Shaheen Akhondzadeh and colleagues
at the Tehran University of Medical Sciences and the Institute of
Medicinal Plants (both in Tehran, Iran) treated 36 patients diagnosed
with GAD with P. incarnata extract, oxazepam, or placebo in a 4-week
trial.
The extract and the drug gave equally positive results. Oxazepam
acted more rapidly, but it also impaired the subjects’ job performance
whereas the extract did not. In the time since this report was issued,
however, there is no record of US Food and Drug Administration filings
for chrysin, harman, or passionflower extracts.
This discussion of anxiety remedies reminds us that today is the beginning of Mental Health Awareness Week.
N-(1-Phenylpyrazol-3-yl)-N-[1-(2-phenylethyl)-4-piperidyl]propanamide
The oxalate salts and free bases of fentanyl and
N-[1-(2-phenylethyl)-4-piperidyl]-N-(1-phenyl-4-pyrazolyl)propanamide, a
new lead compound for long-acting analgesia, have been characterized by
(1)H- and (13)C-NMR spectroscopy. The crystal structure of the
hydrochloride of
N-[1-(2-phenylethyl)-4-piperidyl]-N-(1-phenyl-4-pyrazolyl)propanamide
monohydrate has been determined.
N-Phenyl-N-(4-piperidinyl)propanamide HCL
Two centrosymmetrically related cations, joined through C(phenyl)-H
em leader pi contacts, encapsulate a large void that contains pairs of
anions and bridged water molecules into a zero-dimensional (0D)
supramolecular motif. The cations are linked to this framework via N(+)H
em leader Cl(-) contacts. GIAO/B3LYP calculations have been carried out
to compare the experimental (13)C chemical shifts with the absolute
shieldings thus calculated. The protonation of both molecules takes
place on the piperidine ring (axial protonation), as has been verified
both in the solid state (X-ray) and in solution (NMR).
372,000 children in China are now enrolled in an international style of
education and 66% of these children are Chinese nationals attending
international Chinese-owned private schools in the country.
Educational Leadership training china
Latest market trends from ISC Research on international education in
China include data from this school year (2018-2019). They show that the
international private schools market in China has grown substantially
due to an increasing demand from Chinese parents for an international,
bilingual approach to learning for their children.
Five years ago, there were 629 international schools in China, many of
which were schools for the children of foreign nationals that had very
limited access to Chinese children. Today, there are 857 international
schools in China and 563 of them are international Chinese-owned private
schools. Over that same period, there has been a 63.6% increase in
student enrolment, with 245,500 students now enrolled in the
international Chinese private schools.
These schools are particularly successful because, during the compulsory
years of education, the Chinese curriculum can be integrated with
elements of international teaching and learning, including some learning
in the language of English. Such a bicultural educational approach is
what a growing number of Chinese families want; one that retains local
culture and history, while introducing international elements that
provide the skills necessary to prepare children for global higher
education and careers.
There are several factors that have prompted this market change
including an increase in education expenditure by more families as a
result of a growth in prosperity in the country; the impact of China's
two-child policy which is now seeing an effect within Early Years
education; amendments that have been made to education regulations in
recent years which now provide clearer guidelines and more opportunities
for foreign schools to engage with the private education sector; and an
increasing awareness by Chinese parents of locally accessible private
international education opportunities.
Foreign education brands are driving the success of many of the
international Chinese private schools. During the past five years, 31
independent school brands, mostly from the UK, but also from the US,
have established agreements with Chinese schools and investors in order
to deliver teaching expertise and an international style of education.
Such partnerships are appealing to wealthier Chinese families who value
the educational heritage, reputation, brand prestige, and opportunities
that the UK and US schools are bringing to China.
International schooling options accessible to local families are
available in many of China's Tier 1 cities. Although Shanghai and
Beijing dominate, there are now 55 international schools in Shenzhen, 47
in Guangzhou, 25 in Chengdu, and several in a growing number of cities
throughout China.
ISC Research is aware of at least 48 new international schools due to
open in China in the next few years, many of which will be the
international Chinese private schools partnering with foreign
independent school brands.
ISC Research supplies primary-source intelligence and data - much of it
collected by its own field-based researchers - on the English-medium
K-12 international schools market in key countries most appropriate for
international school development, including China. The ISC China Market
Intelligence Report supports schools, investors and developers with
detailed data and market intelligence to support due diligence and
strategic planning for new school developments and agreements. The data
and intelligence in this report is gathered directly from schools,
government bodies and reputable associations in China to produce
detailed demand analysis of this developing market.
Off the court, the sixth-grader from Wuxi, in eastern China’s Jiangsu
province, speaks quietly and gently. But when it’s game time, she’s
laser-focused as she chases the ball, moving energetically across the
court.
Children tennis in Shanghai
Despite an overall trend of declining health and athleticism among
Chinese children, a growing number of young people are taking up tennis —
a sport invented in the U.K. in 1873 that barely existed in China less
than two decades ago.
Like many others, Ni began playing tennis in 2011, when China’s former
world No. 2 women’s tennis player Li Na became the first from Asia to
win the Grand Slam championship title at the French Open. Li’s success
led to a domestic tennis fever, and that same year, Ni’s father and
coach, Xi Zhiye, began training his then-5-year-old daughter.“There was a
surge in the number of Chinese teenagers starting to learn tennis that
year — some of the parents thought the sport could be a possible future
for their children,” said Xi, who quit his job in securities trading two
years ago to focus on his daughter’s tennis training.
In her age group, Ni is a top player: Last year, she won third place in
the national Zheng Jie Cup teen tennis tournament. The 11-year-old is a
short-distance runner and a soccer player on the school teams, but it’s
her tennis ability cultivated over six years of intensive training that
has won her the most medals.
“I like playing tennis. It helps me relax after school,” Ni told Sixth
Tone. “I’m the only one at my school who plays tennis, but I don’t feel
lonely — I make friends at different tournaments, and they’re all
excellent tennis players.”
The number of tennis players registered at Shanghai’s 16 government-run
children’s sports clubs has increased tenfold since 2007, from 100 to
1,075 today, according to the city’s tennis association. A decade ago,
only five of the 16 district clubs offered tennis, but now each has a
team, said Xue Lei, vice secretary-general of the association. Tennis is
also being offered at schools alongside other sports as part of a wider
push by the Chinese government to encourage children to stay active.
Xue attributes the increased interest in youth tennis to the sport’s
growing profile in China. In 1998, the international tennis tournament
Heineken Open came to Shanghai, making it the first world-class tennis
competition in the country. The Tennis Masters Cup and ATP World Tour
Masters 1000 tournaments followed a few years later. Earlier this month,
the Shanghai Masters entered its ninth year, drawing top international
players like men’s singles champion Roger Federer.
“Many young parents today grew up watching these tennis games or
following a certain star tennis player,” said Xue. “Motivated by their
own interest in the sport, they started bringing their children to the
court.”
This is certainly true for Ni, whose father began playing tennis as a
hobby in the late 1990s and remains a loyal fan of Federer. Xi couldn’t
wait to start teaching his daughter the sport when she turned 5 —
considered the minimum age for children to start tennis
training.school’s permission — and takes her to the court for her
two-hour tennis practice. After dinner, she spends an hour on homework
and goes to bed by 9:30 p.m.
Height is one barrier to playing tennis professionally. Top female
tennis players must be relatively tall to reach the ball, but not so
tall that their height slows them down. Ni undergoes bone age
assessments every year to track her skeletal development, and current
estimates suggest the 155-centimeter-tall girl could grow to between 172
centimeters and 175 centimeters — tall enough to pursue a professional
tennis career. (By comparison, China’s top female tennis player, Li, is
172 centimeters tall.)
Ni’s father believes the real challenges lie ahead, when his daughter
may be forced to choose between athletics and academics. While Xi
believes university studies are a must, he doesn’t want her tennis
training to go to waste. “In the U.S., there’s no contradiction between
sports and academic studies, but in China, it’s the reality,” he
explained. “Without appropriate academic learning, I’m afraid Ni would
fall behind in terms of general knowledge and communication skills.”
Concordia’s Middle School works in partnership with parents to create a
school community that is supportive and responsive to student needs.
Children between the ages of 10 and 14 are unique in intellectual,
social, emotional, and physical growth. Recognizing that these children
are also strikingly different from each other, the middle school is
designed to meet the needs of a child as well as an adolescent during
the transition from the elementary to high school. Through a caring and
secure environment, the middle school program ensures that all students
experience challenge and success.
International middle school
At Concordia our Middle School program is based upon the developmental needs of the young adolescent with the following goals:
Mastering basic skills within an interdisciplinary context.
Acquiring a fundamental body or knowledge and the critical thinking skills necessary for its interpretation and application.
Developing and maintaining a positive self-image.
Accepting increased social, personal and academic responsibilities.
Exploring a diversity of curricular and extracurricular activities.
Developing an increased awareness of individual differences and respect for others.
Participating responsibly in the school community.
On Sunday, tens of thousands of professional and amateur runners will
hit the streets of Britain's capital for the London Marathon, one of the
world’s most prestigious long-distance running races.But while any
doctor can tell us the benefits of exercise, there are some experts who
believe that marathon-length runs - just over 26 miles - are too extreme
for the average runner, and can be dangerous.To get more
marathon length, you can visit shine news official website.
Virgin, which sponsors the London Marathon, says that “running is good
for the heart” and stresses that more than one million people have
safely completed the marathon in its 38-year history, but acknowledges
that there have still been “several fatalities from serious heart
disease in runners apparently unaware that they had a problem”.
Since the first event in 1981, a total of 12 participants have died, the
most recent of whom was former Masterchef semi-finalist Matt
Campbell.Campbell collapsed and died during last year’s marathon, when
temperatures hit an all-time high for the event.This news was followed
just a few months later by reports that two men had died after
collapsing at the finish line of the Cardiff Half Marathon in October
2018.
The competitors, aged 25 and 32, “went into cardiac arrest after
crossing the finishing line within three minutes of each other, at about
12.25pm”, reports the BBC.Given the number of people who take part in
such races each year, just how dangerous is long-distance running?
How safe are marathons?
The BBC reports that most of the casualties that occur during a race
concern minor injuries, like pulled muscles, sprains and strains. These
tend to heal quickly and on their own.
The broadcaster adds that dehydration is the biggest problem that
marathon runners have to overcome. “In a hard race on a hot and humid
day, up to four litres of fluid can be lost through sweating and
exhalation,” it says. “It is important for runners to keep well
hydrated.”
But an increasing number of studies are now linking long-distance
running with sudden heart conditions and issues that were undetected
previously, even if there is no family history of similar health issues.
In a study published in December in the journal Circulation, researchers
in Spain revealed that full marathons may put significant strain on the
heart. In order to do this, the team measured substances that can
signal stress and found higher levels in runners who covered the classic
26.2 mile (42.2 kilometres) marathon distance compared with those who
raced shorter distances such as a half-marathon or 10K, Health24
reports.
A study presented to the American College of Cardiology in 2009 found
that the risk of sudden death during a marathon is 0.8 per 100,000
people. By comparison, the report found that triathlons – which ask
users to complete three sequential endurance races in swimming, running
and cycling – have a significantly higher risk of sudden death at 1.5 in
100,000. To put this into perspective, the risk of dying in childbirth
in the UK in 2012 was 8.6 in 100,000 births, according to The Daily
Telegraph.
How does it affect the heart?
A number of independent studies have found that marathons appear to
cause damage to the heart in the short term, but researchers are unsure
whether the effects are lasting. Some note that there are cardiovascular
advantages to regular running. “Being fit is protective,” Dr James
Freeman, a fellow in cardiovascular medicine at Stanford University
School of Medicine told The New York Times. Professor Sanjay Sharma,
medical director for the London Marathon, told the BBC that most people
who have died during the London marathon have had previous heart
conditions or heart disease.
In 2013, President Xi Jinping proposed that China would create a “Silk
Road Economic Belt” across Central Asia and Europe and a “21st Century
Maritime Silk Road” running through the South China Sea and the Indian
Ocean, on to the Middle East and Europe — programs meant to revive
ancient trade routes and reinforce existing ones. Beijing quickly wove
these two visions together and dubbed them the Belt and Road Initiative
(BRI).To get more
belt and road, you can visit shine news official website.
While seemingly aimed at regional economic corridors, the BRI is in fact
global and motivated by economic and strategic interests. A successful
BRI would allow China to more efficiently utilize excess savings and
construction capacity, expand trade, consolidate economic and diplomatic
relations with participating countries, and diversify China’s import of
energy and other resources through economic corridors that circumvent
routes that are controlled by the U.S. and its allies.
The initiative is generally popular in the developing world, where
almost all countries face infrastructure deficiencies and a shortage of
resources to overcome them. Through large amounts of loans to
participating countries to construct infrastructure in various sectors,
the BRI can potentially bring significant benefits to these countries by
filling their infrastructure gaps and boosting economic growth.
While popular with developing countries, the initiative has received
various criticisms from advanced industrial economies: that the program
lacks transparency and serves to facilitate China’s export of its
authoritarian model; that the commercial loan terms are bringing on a
new round of debt crises in the developing world; and that the projects
have inadequate environmental and social safeguards.
This paper examines the implementation of BRI infrastructure projects in
Africa in light of available information and concludes that African
experiences with the BRI are quite heterogeneous. Some of the major
borrowers have debt sustainability problems, while others have
integrated the loans from China into sound overall macroeconomic
programs. Some of the major borrowers are authoritarian countries with
poor records of human rights, but other major participants are among the
more democratic countries of Africa. It is hard to make simple
generalizations about BRI in Africa. For this reason, it would be wise
for Western countries to tone down their rhetoric on BRI, as many of the
projects will probably work out well. It would help if Western
countries provided more support to the International Monetary Fund to
help countries manage their borrowing and to the World Bank to provide
more infrastructure financing that increased options for the developing
countries of Africa.
Hot Sale CAS 82640-04-8 Raloxifene HCl Powder with Best Price
What is Raloxifene HCL ?
Raloxifene HCL is an oral selective estrogen receptor modulator
(SERM) that has estrogenic actions on bone and anti-estrogenic actions
on the uterus and breast. Raloxifene HCL is used in the prevention of
osteoporosis in postmenopausal women.
Raloxifene powder
Fuction of Raloxifene HCL
Raloxifene HCL is used to prevent and treat osteoporosis (condition
in which the bones become thin and weak and break easily) in women who
have undergone menopause (change of life; end of menstrual periods).
Raloxifene HCL is also used to decrease the risk of developing
invasive breast cancer (breast cancer that has spread outside of the
milk ducts or lobules into the surrounding breast tissue) in women who
are at high risk of developing this type of cancer or who have
osteoporosis.
Raloxifene HCL cannot be used to treat invasive breast cancer or to
prevent invasive breast cancer from coming back in women who have
already had the condition.
Raloxifene HCL also cannot be used to decrease the risk of
developing non-invasive breast cancer. Raloxifene HCL is in a class of
medications called selective estrogen receptor modulators (SERMs).
Raloxifene HCL prevents and treats osteoporosis by mimicking the effects
of estrogen (a female hormone produced by the body) to increase the
density (thickness) of bone.
Raloxifene HCL decreases the risk of developing invasive breast cancer by blocking the effects of estrogen on breast tissue.
Raloxifene HCL may stop the development of tumors that need estrogen to grow.
Application of Raloxifene HCL
Raloxifene Hydrochloride is an active pharmaceutical ingredient used
to prevent osteoporosis in postmenopausal women and to reduce the risk
of invasive breast cancer in postmenopausal women with osteoporosis and
in postmenopausal women at high risk for invasive breast cancer.
High Purity and High-Speed Delivery
Anastrozole Acetate
Arimidex, Cas No: 120511-73-1, Anastrozole Acetate, Anastrol
Arimidex Description:
Ana strozoles
Arimidex Alias: Arimidex
Arimidex CAS No: 120511-73-1
Arimidex MF: C17H19N5
Arimidex MW: 293.37
Arimidex Purity: 98%min
Arimidex Appearance: White crystalline powder.
Arimidex Usage: An aromatase inhibitor. Used as an antineoplastic raw materials.
Potent selective triazole aromatase inhibitors, can inhibit the
cytochrome P-450 aromatase enzyme which depends blocking the
biosynthesis of estrogen, and estrogen to stimulate breast cancer cell
growth factors. Treatment of breast cancer, especially for those with
hormone relapse after adjuvant therapy after menopause for women with
advanced breast cancer.
Arimidex Applications:
The drug is appropriately used when using substantial amounts of
aromatizing steroids, or when one is prone to gynecomastia and using
moderate amounts of such steroids. Arimidex does not have the side
effects of aminoglutethimide (Cytadren) and can achieve a high degree of
estrogen blockade, much moreso than Cytadren. It is possible to reduce
estrogen too much with Arimidex, and for this reason blood tests, or
less preferably salivary tests, should be taken after the first week of
use to determine if the dosing is correct.
Appearance: Off-white crystalline powder
Packing: Aluminum foil bag+cardboard box, 100 grams/bag; 500 grams/bag; 1kg/bag
Used: Raw material powder
Min. Order quantity: 5g
Terms of payment: T/T, Western Union, Money Gram
Way of shipping: EMS, DHL, FedEx, UPS
Product info.
No Side Effect Arimidex Steroid Healthly Anti Estrogen Hormone
Anastrozole Arimidex is a non-steroidal drug which is used to treat
breast cancer. It has been thoroughly studied in women with breast
cancer between the 5th-8th decades of life. There are some breast
cancers which are dependent on estrogen for their growth. Arimidex acts
by suppressing the levels of estrogen in the body and thus reduces the
growth of breast cancer. The drug is first line treatment in post
menopausal women with early breast cancer or in those with advanced
breast cancer despite taking tamoxifen. Arimidex is often combined with
other drugs to treat breast cancer in post menopausal women. The drug
has been used to treat early or advanced breast cancer in women all
cultures and races.
β-agonist Powder
The trial suggested that is the preferred medical therapy for
Postmenopausal women with localized breast cancer that is estrogen
receptor (ER) positive.
Three azole potent selective aromatase inhibitors, which inhibit rely on
aromatase cytochrome P -450 to block estrogen biosynthesis, and the
main factors of estrogen to stimulate breast cancer cell growth. It can
treat breast cancer, especially suitable for those who relapse after
treatment with hormone auxiliary advanced breast cancer after menopause
women.
The chemical name for Timolol maleate is
(S)-1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol
(Z)-2-butenedioate (1:1) salt. It possesses an asymmetric carbon atom
in its structure and is provided as the levo isomer. Its molecular
formula is C13H24N4O3S•C4H4O4and its structural formula is:
Timolol maleate has a molecular weight of 432.50. It is a white,
odorless, crystalline powder which is soluble in water, methanol, and
alcohol.Timolol maleate is supplied as tablets containing 5 mg, 10 mg
and 20 mg Timolol maleate for oral administration. Inactive ingredients
are: colloidal silicon dioxide, croscarmellose sodium, magnesium
stearate, microcrystalline cellulose, pregelatinized maize starch,
sodium lauryl sulfate.
Timolol
CLINICAL PHARMACOLOGY
Timolol maleate is a beta1 and beta2 (nonselective) adrenergic receptor
blocking agent that does not have significant intrinsic sympathomimetic,
direct myocardial depressant, or local anesthetic activity.
Pharmacodynamics
Clinical pharmacology studies have confirmed the beta-adrenergic
blocking activity as shown by (1) changes in resting heart rate and
response of heart rate to changes in posture; (2) inhibition of
isoproterenol-induced tachycardia; (3) alteration of the response to the
Valsalva maneuver and amyl nitrite administration; and (4) reduction of
heart rate and blood pressure changes on exercise.
Timolol decreases the positive chronotropic, positive inotropic,
bronchodilator, and vasodilator responses caused by beta-adrenergic
receptor agonists. The magnitude of this decreased response is
proportional to the existing sympathetic tone and the concentration of
Timolol at receptor sites.In normal volunteers, the reduction in heart
rate response to a standard exercise was dose dependent over the test
range of 0.5 to 20 mg, with a peak reduction at 2 hours of approximately
30% at higher doses.
Beta-adrenergic receptor blockade reduces cardiac output in both healthy
subjects and patients with heart disease. In patients with severe
impairment of myocardial function beta-adrenergic receptor blockade may
inhibit the stimulatory effect of the sympathetic nervous system
necessary to maintain adequate cardiac function.
Beta-adrenergic receptor blockade in the bronchi and bronchioles results
in increased airway resistance from unopposed parasympathetic activity.
Such an effect in patients with asthma or other bronchospastic
conditions is potentially dangerous.
Clinical studies indicate that Timolol maleate at a dosage of 20 to 60
mg/day reduces blood pressure without causing postural hypotension in
most patients with essential hypertension. Administration of Timolol to
patients with hypertension results initially in a decrease in cardiac
output, little immediate change in blood pressure, and an increase in
calculated peripheral resistance. With continued administration of
Timolol, blood pressure decreases within a few days, cardiac output
usually remains reduced, and peripheral resistance falls toward
pretreatment levels. Plasma volume may decrease or remain unchanged
during therapy with Timolol. In the majority of patients with
hypertension Timolol also decreases plasma renin activity. Dosage
adjustment to achieve optimal antihypertensive effect may require a few
weeks. When therapy with Timolol is discontinued, the blood pressure
tends to return to pretreatment levels gradually. In most patients the
antihypertensive activity of Timolol is maintained with long-term
therapy and is well tolerated.
The mechanism of the antihypertensive effects of beta-adrenergic
receptor blocking agents is not established at this time. Possible
mechanisms of action include reduction in cardiac output, reduction in
plasma renin activity, and a central nervous system sympatholytic
action.
A Norwegian multi-center, double-blind study, which included patients 20
to 75 years of age, compared the effects of Timolol maleate with
placebo in 1,884 patients who had survived the acute phase of a
myocardial infarction. Patients with systolic blood pressure below 100
mm Hg, sick sinus syndrome and contraindications to beta-blockers,
including uncontrolled heart failure, second- or third-degree AV block
and bradycardia (< 50 beats per minute), were excluded from the
multi-center trial. Therapy with Timolol, begun 7 to 28 days following
infarction, was shown to reduce overall mortality; this was primarily
attributable to a reduction in cardiovascular mortality. Timolol
significantly reduced the incidence of sudden deaths (deaths occurring
without symptoms or within 24 hours of the onset of symptoms), including
those occurring within one hour, and particularly instantaneous deaths
(those occurring without preceding symptoms). The protective effect of
Timolol was consistent regardless of age, sex or site of infarction. The
effect was clearest in patients with a first infarction who were
considered at a high risk of dying, defined as those with one or more of
the following characteristics during the acute phase: transient left
ventricular failure, cardiomegaly, newly appearing atrial fibrillation
or flutter, systolic hypotension, or SGOT (ASAT) levels greater than
four times the upper limit of normal. Therapy with Timolol also reduced
the incidence of nonfatal reinfarction. The mechanism of the protective
effect of Timolol is unknown.
Timolol was studied for the prophylactic treatment of migraine headache
in placebo-controlled clinical trials involving 400 patients, mostly
women between the ages of 18 and 66 years. Common migraine was the most
frequent diagnosis. All patients had at least two headaches per month at
baseline. Approximately 50 percent of patients who received Timolol had
a reduction in the frequency of migraine headache of at least 50
percent, compared to a similar decrease in frequency in 30 percent of
patients receiving placebo. The most common cardiovascular adverse
effect was bradycardia (5.