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nootropic powder piracetam coluracetam fasoracetam prl-8-53 Nootropics also referred to as smart drugs, memory enhancers, neuro enhancers, cognitive enhancers, and intelligence enhancers, are drugs, supplements, nutraceuticals, and functional foods that purportedly improve mental functions such as cognition, memory, intelligence, motivation, attention, and concentration. Nootropics are thought to work by altering the availability of the brain's supply of neurochemicals (neurotransmitters, enzymes, andhormones), by improving the brain's oxygen supply, or by stimulating nerve growth.Coluracetam Racetams The racetams are structurally similar compounds, such as pramiracetam, oxiracetam, coluracetam, and aniracetam, which are often marketed as cognitive enhancers and sold over-the-counter. Racetams are often referred to as nootropics, but this property of the drug class is not well established. The racetams have a poorly understoodmechanisms of action; however, piracetam and aniracetam are known to act as positive allosteric modulators of AMPA receptors and appear to modulate cholinergicsystems. Aniracetam Aniracetam is an ampakine nootropic of the racetam chemical class purported to be considerably more potent than piracetam. It is lipid-soluble and has possible cognition-enhancing effects. It has been tested in animals extensively, Alzheimer’s patients, and temporarily impaired healthy subjects. It has shown potential as an anxiolytic in three clinical animal models. It is sold in Europe as a prescription drug, but it is not approved by the Food and Drug Administration for use in the United States. Piracetam Piracetam is a cognitive enhancer and memory enhancing supplement. Many people across the world use the nootropic, piracetam, to effectively retain knowledge andimprove memory. Piracetam is utilized by both younger and older healthy individuals. From recent and past clinical studies and research, Piracetam has been determined to support memory and aid individuals experiencing memory loss and difficulties in the ability to retain knowledge. Piracetam may enhance, elevate, and improve cognitive functions and abilities linked and associated to the central nervous system, memory development and memory processes. Pramiracetam Pramiracetam is a lipid-soluble nootropic of the Racetam chemical family, and has a relatively similar chemical structure compared to its cousin Aniracetam. However, this nootropic is much stronger than Aniracetam. Pramiracetam has the capabilities of increasing the long term memory of individuals, allowing obtained information and knowledge to be recalled more easily. Considering that the high-affinity choline uptake (HACU) is increased implies an increase in the synthesis and release of Acetylcholine. The information shows how this smart drug increases both the Hippocampal Acetylcholine activity and the learning and memory encoding process. Sunifiram Sunifiram is a research ampakine that is becoming very popular amongst researchers. As an ampakine, it works to improve the ability of the AMPA glutamate receptors. Sunifiram works by stimulating the AMPA receptor currents therefore improving the glutamate signal. This is believed to be the main method of action however there are several other applications of this compound. Unifiram Unifiram is the cousin of sunifiram. It is very similar in structure and the effects are supposedly similar. Unifiram is thought to be a slightly more potent compound than sunifiram. It is becoming very popular amongst nootropics researchers worldwide. Coluracetam Coluracetam is another nootropic in racetam chemical class. The effects of coluracetam are supposedly similar to the cousin racetam, pramiracetam. Its’ main function is to improve High Affinity Choline Uptake (HACU). HACU has some great effects on the cholinergic applications on cognitive function. This is another exciting compound indeed. IDRA-21 This is another ampakine nootropic and it belongs to the benzothiadiazine family. IDRA-21 is less researched than sunifiram and unifiram. Preliminary animal studies have shown positive results on reducing drug induced defects. The compound does not appear to show neurotoxicity when administered alone. IDRA-21 is a highly sought after compound for avid nootropic researchers. PRL-8-53 PRL-8-53 is of great interest to nootropic researchers. It has had some human studies which showed positive responses in cognitive function. One study showed that the compound could help retrieve lost memories (hypermnesia). Research on PRL-8-53 in medical applications has come to a standstill however many independent nootropic researchers have got it on their crosshairs. The method of action of PRL-8-53 is not fully understood. It does possess cholinergic properties. It is also thought that PRL-8-53 may potentiate dopamine functions while inhibiting serotonin. Many aspect of this compound are still a mystery.

High Quality Peptide Powder Alarelin 99% purity in UK HK USA warehouse Alarelin powder is known for its induction of ovulation. Alarelin acetate is the acetate form of a hypothalamic peptide that stimulates the release of FSH and LH from the pituitary gland. 2> Alarelin is commonly used in research settings both to better understand this peptide’s effects on an animal’s body and to induce conditions that may assist with reproductive research. Samples of this chemical intended for research settings are typically stable for around three weeks at room temperature,and will need to be stored at temperatures below -18 degrees Celsius for long term use. 3> increase the dermis collagen synthesis; to promote DEJ formation and reinforcement of dermal connective tissue (skin); promote epidermal cells differentiation of mature. 4> So used to skin the effect is significant, anti-wrinkle;Powerful repair;Against loose skin, make skin more elastic and more tight.

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BPC 157 powder has a strong anti-inflammatory activity in both acute and chronic inflammation models.In fact, preliminary results in clinical trials suggest that BPC 157 may become an important therapeutic tool for the treatment of inflammatory bowel disease.BPC 157 was shown to accelerate wound healing and to have a marked angiogenic effect.In addition, it significantly facilitates the healing of bone fracture in rats.This peptide also exhibits an osteogenic effect significantly improving the healing of segmental bone defect.BPC 157 accelerates the healing of transected rat Achilles tendon and transected rat quadriceps muscle.

FITC-phalloidin staining was able to demonstrate that BPC 157 induces F-actin formation in fibroblasts.
Likewise,Western blot analysis was able to detect the production and activation of paxillin and FAK proteins.The western blot analysis also showed that BPC 157 increases the extent of phosphorylation of paxillin and FAK proteins without affecting the amounts produced.
Quick Details
CAS No.:
137525-51-0
Other Names:
bpc-157 peptides
MF:
C62H98N16O22
EINECS No.:
137525-51-0
Place of Origin:
Guangdong, China
Type:
Auxiliaries and Other Medicinal Chemicals
Grade Standard:
Medicine Grade
Brand Name:
Mall
Model Number:
137525-51-0
Purity:
Min 99%
Product Name:
BPC 157
Appearance:
White Fine Powder
CAS:
137525-51-0
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HPLC 99%
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2 Years
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Lab Supply&Better Price Teriparatide Acetate CAS 52232-67-4

Teriparatide Acetate powder is a recombinant form of parathyroid hormone consisting of the first (N-terminus) 34 amino acids, which is the bioactive portion of the hormone. It is an effective anabolic(i.e., bone growing) agent used in the treatment of some forms of osteoporosis. It is also occasionally used off-label to speed fracture healing. Teriparatide is identical to a portion of human parathyroid hormone (PTH) and intermittent use activates osteoblasts more than osteoclasts, which leads to an overall increase in bone.
Teriparatide is the only anabolic (i.e., bone growing) agent indicated for use in postmenopausal women with osteoporosis at a high risk for fracture or with a history of osteoporotic fracture, patients with multiple risk factors for fracture, and for patients who have failed or are intolerant to other available osteoporosis therapy. It has been FDA-approved since 2002. It is effective in growing bone (e.g., 8% increase in bone density in the spine after one year)[6"> and reducing the risk of fragility fractures. Osteoporosis medications are generally safe, but some side effects of teriparatide include headache, nausea, dizziness, and limb pain.

GMP grade best triptorelin acetate bodybuilding peptide Triptorelin powder

Triptorelin Acetate powder, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-PRO-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction. Triptorelin is marketed under the brand names Decapeptyl (Ipsen) and Diphereline and Gonapeptyl (Ferring Pharmaceuticals).
Quick Details
CAS No.:
57773-63-4
Other Names:
Trifluoroacetate-d5
MF:
C66H80F3N18O15
EINECS No.:
N/M
Place of Origin:
Jiangsu, China
Type:
Auxiliaries and Other Medicinal Chemicals
Grade Standard:
Medicine Grade
Usage:
Animal Pharmaceuticals
Brand Name:
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in vial
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Best Quality Triptorelin Acetate Peptide Powder 2mg for Muscle Gain

Triptorelin Acetate powder is usually given as an injection at your doctor's office, hospital, or clinic. If you will be
using triptorelin at home, a health care provider will teach you how to use it. Be sure you understandhow to use triptorelin. Follow the procedures you are taught when you use a dose. Contact yourhealth care provider if you have any questions.Triptorelin is injected into the muscle.Rotate the injection site. Do not inject into an area of skin that is red, hard, or bruised, or has scarsr stretch marks.Do not use triptorelin if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.Keep this product, as well as syringes and needles, out of the reach of children and away from pets.Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use.

Description :
Triptorelin is a releasing hormone agonist used as the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of luteinizing hormone and follicle stimulating hormone.
Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions, and in assisted reproduction. Triptorelin is marketed under the brand names Decapeptyl and Diphereline and Gonapeptyl.
Application :
Triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions, and in assisted reproduction. Triptorelin is marketed under the brand names Decapeptyl and Diphereline and Gonapeptyl.
In the United States, it is sold by Watson as Trelstar.In Iran Triptorelin is marketed under the brand name Variopeptyl.In India, Dr. Reddy's Laboratories has launched recently Triptorelin under the brand name "Pamorelin LA". During the treatment of prostate cancer it does cause a surge, known as a flare effect. In men a reduction of serum levels into the range normally seen after surgical castration occurs approximately two to four weeks after initiation of therapy.

Basic Info.
CAS:33515-09-2
Sequence:P-Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
MF:C55-H75-N17-O13
MW:1182
Purity:99%
Specification:2mg/vial, 10mg/vial
Appearance:White Lyophilized Powder
Standard:USP
Storage: Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18 C. Upon reconstitution of the peptide it should be stored at 4 C between 2-21 days and for future use below -18 C.Gonadorelin Acetate powder,Gonadorelin powder

Description
Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens. The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use.
Gonadorelin USAGE

For evaluating the functional capacity and response of the gonadotropes of the anterior pituitary also for evaluating residual gonadotropic function of the pituitary following removal of a pituitary tumor by surgery and/or irradiation.
Gonadorelin is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens. The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use
Systemic - Like naturally occurring releasing hormone (GnRH), gonadorelin primarily stimulates the synthesis and release of luteinizing hormone (LH) from the anterior pituitary gland. Follicle-stimulating hormone (FSH) production and release is also increased by gonadorelin, but to a lesser degree. In prepubertal females and some gonadal function disorders, the FSH response may be greater than the LH response. For the treatment of amenorrhea, delayed puberty, and infertility the administration of gonadorelin is used to simulate the physiologic release of GnRH from the hypothalamus in treatment of delayed puberty, treatment of infertility caused by hypogonadotropic hypogonadism, and induction of ovulation in those women with hypothalamic amenorrhea. This results in increased levels of pituitary LH and FSH, which subsequently stimulate the gonads to produce reproductive steroids.

Metenolone enanthate, or methenolone enanthate, is a dihydrotestosterone (DHT)-based anabolic steroid. It is an ester derivative of methenolone sold commonly under the brand names Primobolan (tablet form) or Primobolan Depot (injectable). When it interacts with the aromatase enzyme it does not form any estrogens.[medical citation needed] It is used by people who are very susceptible to estrogenic side effects, having lower estrogenic properties than nandrolone. Methenolone, in form of enanthate and acetate, is available as an injection or as an oral formulation. The injection is regarded as having a higher bioavailability. It is an enanthate ester which is quite long-acting. Because it by-passes hepatic breakdown on the first pass, it also has a higher survival rate. The tablets are in a short-lived acetate form. Methenolone is not 17-alpha-alkylated, but 1-methylated for oral bioavailability. This reduces the stress on the liver, but also the availability. In doses of 200 mg per week or less (intramuscular) blood pressure is rarely altered.Test E (Test P) dosage

Methenolone can be suppressive of the hypothalamic-pituitary-gonadal axis.

Application :

Methenolone enanthate is a very popular option particularly for athletes leaning out and attempting to maintain as much muscle as possible during calorie restriction. Many competitive bodybuilders would not consider a pre-contest stack with out the addition of methenolone. It is an anabolic steroid , widely used in the new metabolism , prevention of osteoporosis and so on .

Protein assimilatio , the protein hormone assimilation strong activity of the liver, and the small toxicity . Methenolone Enanthate is a dihydrotestosterone based anabolic steroid , Methenolone Enanthate is an ester derivative of methenolone sold commonly under the brand name primobolan , Methenolone Enanthate is used by people who are very susceptible to estrogenic aide effect , having lower estrogenic properities than nandrolone, methenolone , in form of enanthate and acetate , Methenolone has no estrogenic side effects and its effects on cholesterol , Methenolone is also not overly suppressive of the HPTA axis , for this reason , mang bodybuilder use Methenolone in between steroid cycles .

Nandrolone Phenylpropionate
Alias: Nandrolone Decanoate dosage
CAS No: 62-90-8
Einecs No: 200-551-9
MF: C27H34O3
MW: 406.56
Purity: 98%min
Appearance: White powder, special smell, dissolve in ethanol, slightly soluble in vegetable oil, almost insoluble in water.
Refrigeration save: Room temperature more than 20 Celsius degree to agglomerate, or so 30 Celsius degree into a liquid.

Product description

Libriol and Tribolan are trade names for Nandrolone Phenylpropionate, another exotic anabolic preparation coming out of an Australian company, RWR, which is shrouded in mystery. Anabolic NA is Syd Group's entry into this bizarre combination of steroids. They all seem to be of popular demand in bodybuilding circles primarily because of this mystique. I will look at the pros and cons of this obscure drug, Nandrolone Phenylpropionate, and if it qualifies to be in the muscle building, fat-melting cycles of our future.
Libriol is an injectable veterinary product containing short esters of the drugs nandrolone and methandriol. Anabolic NA has the rare Nandrolone Cypionate, and Tribolan contains the very long estered Nandrolone Decanoate. Steroid. COM members should immediately recognize the first drug, nandrolone. A steroid derived from modifying the testosterone molecule, Nandrolone is one of the most popular drugs in the world and with good reason; It is a versatile steroid that can be used in "bulking" or "cutting" cycles.
Applications:

Nandrolone Phenylpropionate (NPP) is the lesser known and less popular phenylpropionate ester version of nandrolone. First off its important to understand the difference between what we know as 'deca' and what we know as "NPP". To put it in simple terms the difference is simply the ester. NPP has the shorter ester while deca durabolin version of nandrolone has the longer 'deca' ester. Many lifters have no clue they can use the compound they love so much in a shorter ester. The only disadvantage would be the amount of injections, the shorter ester would have to be injected every other day or every 3 days at the most, while the long 'deca' ester can be injected once or twice a week. However the advantages are there which I will discuss as we go along.

To understand the other advantages of using Nandrolone Phenylpropionate we must then understand half lives and what they mean. To put it in simple terms NPP will be quicker to build up to peak levels in the body and will be quicker once you stop injecting to filter out of the body. Deca meanwhile because of the extremely long ester will take much longer to build up and worst of all takes longer to trickle out of the body, this will cause a much longer recovery for those of you who cycle. So deca is a poor choice if you like to keep cycles under 10 weeks and want to run multiple cycles per year, and NPP is a realistic option. Deca Durabolin will take about 6 weeks to clear out of your body and is also detectable for up to 18 months! NPP meanwhile will clear out much faster, I would guestimate about 2-3 weeks at the most where the body can begin recovery. This 3-4 week difference is major when dealing with nandrolones.
Another slight disadvantage with NPP is some users will say the injections can be more painful then the much smoother deca injection. However I can assure you it is nothing as bad as prop.

Quick Detail:
Methenolone Acetate,Primo A (Primo E) dosage
Alias: Primobolan-depot: 1-methyl-3-oxoandrost-1-en-17-yl acetate; (5alpha, 17beta)-1-methyl-3-oxoandrost-1-en-17-yl acetate
Methenolone Acetate CAS No: 434-05-9
Methenolone Acetate Purity: 99%
Methenolone Acetate MF: C22H32O3
Methenolone Acetate MW: 344.49

Einecs No: 207-097-0
MOQ(minimum order quantity): 10gram
Standard: Enterprise Standard
Appearance: White powder.
Usage: It is very strong, the synthesis of the metabolism and male characteristics is very low, making it the best choice for the game.

MOQ(minimum order quantity): 10gram
Standard: Enterprise Standard
Appearance: White powder.
Usage: Anabolic steroid. Androgen. Controlled substance.

Are you looking for something that can help in mass gaining in natural way?

Using anabolic steroids is the best way that help athletes and gym-goers or bodybuilders to make their muscles stronger and keep their stamina maintained. Testosterone Enanthate Powders are one of them that is an anabolic steroid counted as perfect for all levels of use.Buy Primo A (Primo E) powder in bulk

Being the perfect anabolic steroid for the first time steroid user and will be equally effective for the individual with a lot of time in the saddle, Testosterone Enanthate Powders is helpful in carrying with it possible side effects but we will also find they are very easy to control. If this is surprising it really shouldn’t be.

After all, although synthetic it’s simply testosterone, a hormone the human body is not only well-accustomed to but one that is essential to our health and wellbeing. There are a number of added benefits of using it. You have to choose the right dosage and place your order to consume.

Testosterone Enanthate Cycles and Uses

Testosterone Enanthate cycles are usually that of a bulking or mass gaining nature, though it can also be utilized in a very specific manner in cutting or fat loss cycles. For mass gaining or bulking, Testosterone Enanthate is usually employed in a higher dosage (usually a minimum of 500mg per week), and because it is an anabolic steroid with a long ester affixed to it, it will exhibit a longer half-life of around 7 – 10 days, and therefore Testosterone Enanthate cycles are usually run for periods of 10 – 12 weeks or longer.

In both bulking and cutting cycles, Testosterone Enanthate is commonly stacked with other compounds of a nature that will facilitate the user’s end goal (bulking, mass gaining, or fat loss). For example, Testosterone Enanthate cycles for the purpose of bulking usually include the use of Deca-Durabolin (Nandrolone Decanoate) and/or Dianabol (Methandrostenolone), where Dianabol is usually run for the first 6 weeks as a kick-starting compound.

in case of Testosterone Enanthate cycles are cutting or fat loss cycles, Testosterone Enanthate is usually run at a very low TRT (Testosterone Replacement Therapy) dosage of around 100mg per week whilst other compounds more preferable for cutting and fat loss are emphasized during the cycle.

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In order to buy Testosterone Enanthate powder, what all you have to do is search for the right store or reach a reliable supplier. Online search will help you in finding the right supplier. SteroidsFather is a trusted online store offering you Testosterone Enathate Powder with a user guide and information about the potential complications and benefits too.

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Testosterone Enanthate is an anabolic steroid that is perfect for all levels of use. This is the perfect anabolic steroid for the first time steroid user and will be equally effective for the individual with a lot of time in the saddle. It will carry with it possible side effects but we will also find they are very easy to control. If this is surprising it really shouldn’t be. After all, although synthetic it’s simply testosterone, a hormone the human body is not only well-accustomed to but one that is essential to our health and wellbeing.

Testosterone Enanthate Cycles and Uses

Testosterone Enanthate cycles are usually that of a bulking or mass gaining nature, though it can also be utilized in a very specific manner in cutting or fat loss cycles. For mass gaining or bulking, Testosterone Enanthate is usually employed in a higher dosage (usually a minimum of 500mg per week), and because it is an anabolic steroid with a long ester affixed to it, it will exhibit a longer half-life of around 7 – 10 days, and therefore Testosterone Enanthate cycles are usually run for periods of 10 – 12 weeks or longer.

In both bulking and cutting cycles, Testosterone Enanthate is commonly stacked with other compounds of a nature that will facilitate the user’s end goal (bulking, mass gaining, or fat loss). For example, Testosterone Enanthate cycles for the purpose of bulking usually include the use of Deca-Durabolin (Nandrolone Decanoate) and/or Dianabol (Methandrostenolone), where Dianabol is usually run for the first 6 weeks as a kick-starting compound.

In the event that Testosterone Enanthate cycles are cutting or fat loss cycles, Testosterone Enanthate is usually run at a very low TRT (Testosterone Replacement Therapy) dosage of around 100mg per week whilst other compounds more preferable for cutting and fat loss are emphasized during the cycle.

Like everyone else, there is a "safer" way to do this, but "there is no safe way." Tren faces significant health risks, and it must be respected and taken seriously. The following is all you can do (updated in 2016) to help you fight with your sides.Masteron Enanthate powder

Because Tren is 19, and he does not carry the risk of increasing prolactin, which prevents you from going out during sex. This is what prevents you from getting an erection in the first place (tren dick), and this is what gives you breast tissue. Some people will tell you that it's impossible to get a bitch from tren, it's completely wrong, in fact it's a very common side, like most anabolics.
To combat this, you can add to your cycle Dostinex (generic name Caber) or Pramipexole (aka Pramie). Or click here to learn how to prevent Gyno naturally.
Dostinex is good, but it's hard to get, and this hell is much more expensive, it also comes with its own side effects.

If you can not find Dostinex, then Gynectrol is the next best thing. These are natural ingredients, so it's much safer, easier to find and much cheaper. Read more here.

There's also a new answer to fighting cardiovascular problems with Tren, if you can get it, and it's called GW-501516.

By adding the GW-510516 to your cycle, you can counteract negative cardiovascular sides and allow yourself to perform both aerobic and anaerobic cardiovascular exercises in the usual mode.

GW-501516 was banned by WADA (the World Anti-Doping Association) because of the significant advantage it gives to athletes participating in endurance competitions. It normalizes blood pressure, reduces cholesterol and heart rate to a safer level and allows you to improve your health and improve your health.

The optimal dosage of GW-501516 is 20 mg per day, which is good for a period of up to 12 weeks before a 4-week rest period is required. After a rest period, you can restart it.
Not very good news (again!) - even with the above, there are still significant risks with the use of Trenbolone, and you should be aware of them.

Victoza falls under the umbrella of incretin mimetics, a class of drugs used to treat type 2 diabetes that works by boosting insulin production in the pancreas, lowering the patient’s blood sugar levels.Liraglutide powder

Victoza, which is manufactured by Novo Nordisk, was first approved for market in 2010. It quickly became one of the most popular type-2 diabetes treatments.

However, more recently Victoza has faced criticisms over its dangerous side effects, which Novo Nordisk failed to warn consumers about. As a result, a number of Victoza lawsuits have been filed against the manufacturer on behalf of individuals who were injured by Victoza.Byetta (exenatide) is a GLP-1 receptor agonist which mimics the effect of glucagon-like peptide-1, a hormone that increases insulin production when blood sugar is high. Byetta is administered as a twice-daily injection.

Bydureon is also a GLP-1 receptor agonists and contains the same main ingredient as Byetta – exenatide. Bydureon is a longer-lasting version of Byetta, requiring a once a week injection.

Rather than an injection, Januvia (sitagliptin) is a once-daily pill used to lower blood glucose levels in patients with Type 2 diabetes. Januvia helps to increase the insulin produced by the pancreas when blood sugar levels are high and help to reduce the amount of sugar produced by the liver. Also a pill, Janumet is a combination drug – it combines sitagliptin and metformin into a single pill.
Researchers have linked Victoza to a number of dangerous and potentially life-threatening side effects. These side effects were not included on the original Victoza warning label and the public has now been made aware of these side effects by researchers and through drug safety communications.

Pancreatitis and Pancreatic Cancer — Following a number of concerning reports linking Victoza to pancreatitis, the U.S. Food and Drug Administration (FDA) conducted an investigation into Victoza health risks in 2013. The FDA found that pancreatitis was more likely to occur in patients using Victoza than in patients using any other type-2 diabetes medication. As a result, the FDA mandated a black box warning making consumers aware of Victoza’s increased risk of pancreatitis. Other research and studies have shown that this form of type-2 diabetic treatment may be linked to pancreatic cancer. In a recent clinical trial, 13 patients were diagnosed with pancreatic cancer while only 5 patients taking the placebo were diagnosed with pancreatic cancer.
Thyroid Cancer — Following a number of concerning reports linking Victoza to thyroid cancer, the U.S. Food and Drug Administration (FDA) mandated a black box warning for the drug, the strongest warning a drug can carry. Researchers found an increased risk of tumors — sometimes cancerous — developing in the thyroid glands of rats and mice.
If you are taking Victoza and have developed pancreatic cancer, pancreatitis, or thyroid cancer, you should stop taking Victoza and talk to your doctor and an experienced personal injury lawyer right away.

If you had previously taken Victoza and have developed pancreatic cancer, pancreatitis, or thyroid cancer, you should contact an experienced personal injury lawyer right away.

Novo Nordisk has secured approval for Liraglutide powder (liraglutide) from the US Food and Drug Administration (FDA) to treat paediatric patients aged ten years or older with type 2 diabetes.

Victoza is claimed to be the first non-insulin drug approved to treat the condition in paediatric patients. It has been used for adult patients since 2010.

Acting director at the FDA Center for Drug Evaluation and Research’s Division of Metabolism and Endocrinology Products (DMEP) Lisa Yanoff said: “Victoza has now been shown to improve blood sugar control in paediatric patients with type 2 diabetes.

“The expanded indication provides an additional treatment option at a time when an increasing number of children are being diagnosed with this disease.”When administered, Victoza works by creating the same effects in the body as the glucagon-like peptide (GLP-1) receptor protein in the pancreas and improves blood sugar levels.

Victoza slows digestion, prevents the liver from making too much glucose, and helps the pancreas produce more insulin when needed.

It can also be used to reduce the risk of major adverse cardiovascular (CV) events in adults with type 2 diabetes and established CV disease.

Novo Nordisk carried out several placebo-controlled trials in adults and one placebo-controlled trial with 134 pediatric patients to evaluate the efficacy and safety of Victoza for reducing blood sugar in patients with type 2 diabetes.

The drug is not a substitute for insulin and is not indicated for patients with type 1 diabetes or those with diabetic ketoacidosis. No clinical trials were conducted to study the effect of the drug on major adverse CV events in paediatrics.

LISBON – The investigational glucagon-like peptide (GLP)-1 receptor agonist semaglutide added to standard care for type 2 diabetes mellitus (T2DM) resulted in clinically significant weight loss over 2 years in the SUSTAIN-6 phase 3 trial.

Participants treated with semaglutide in the study lost an average of 3.6 to 4.9 kg, depending on the dose they were given (0.5 mg or 1.0 mg), which was significantly (P less than .0001) more than those who were randomized to matching placebos (-0.7 mg and -0.5 mg).“A dose-response effect was observed on weight loss with semaglutide treatment,” study investigator Agostino Consoli, MD, reported at the annual meeting of the European Association for the Study of Diabetes.
Semaglutide is under development by Novo Nordisk and is currently under review by regulatory agencies in the United States, Europe, and Japan. It has 94% homology to human GLP-1 and modifications have been made to help it avoid degradation and which give it a half-life that allows it to be given once a week.
SUSTAIN 6 is part of an ongoing phase 3 program and is a long-term outcome study with the primary objective of evaluating the cardiovascular safety of semaglutide. Effects on macro- and microvascular complications, glycemic control, body weight, body mass index and weight circumference are key secondary endpoints, together with assessment of its overall safety and tolerability.GHRP-2 powder,GHRP 2 powder
Other trials in the program, have evaluated treatment with semaglutide as monotherapy (SUSTAIN 1; Lancet Diabetes Endocrinol. 2017;5:251-60) or versus other treatments including sitagliptin (Januvia, Merck; SUSTAIN 2; Lancet Diabetes Endocrinol. 2017;5:341-54), exenatide extended release (Bydureon, AstraZeneca; SUSTAIN 3), or insulin glargine (SUSTAIN 4), as add-on to basal insulin with or without metformin (SUSTAIN 5), and most recently, versus dulaglutide (Trulicity, Eli Lilly; SUSTAIN 7).

SUSTAIN 6 involved 3,297 people with T2DM with established cardiovascular disease or chronic kidney disease or otherwise identified as being at increased cardiovascular risk, according to Dr. Consoli, who is an endocrinologist and professor at the University of Chieti-Pescara, Italy. The results of the primary endpoint have been reported (N Engl J Med. 2016; 375:1834-44) and showed that the composite rate of cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke was significantly lower among patients receiving semaglutide than among those receiving placebo. The hazard ratio for the reduction in the composite endpoint was 0.74 (95% CI, 0.58-.95; P less than .001 for noninferiority).

Results of the secondary analyses reported by Dr. Consoli at EASD 2017 showed that semaglutide could help more patients than placebo achieve significant weight loss, which could help further reduce their cardiovascular risk. He reported that a 5% or greater weight loss at 2 years was achieved by 36% and 47% of patients treated with semaglutide 0.5 mg and 1 mg groups, respectively, and by 18% and 19% of patients in the matching placebo groups (P less than .0001 for both comparisons). A 10% or greater weight loss was achieved by 13% and 21% of the semaglutide-treated patients and by 6% and 7% of those given placebo.

“The effect of weight was not dependent on BMI [body mass index] at baseline,” Dr. Consoli said, emphasizing that there was a consistent reduction in the weight in all BMI categories. Importantly, Dr. Consoli observed, the effects of semaglutide on weight seen were not driven by just a few patients losing weight, and around 80% of patients in the study experienced some degree of weight loss.

“As expected, the subjects treated with the GLP-1a had more GI [gastrointestinal] effects,” Dr. Consoli reported. Nausea or vomiting were reported in twice as many patients treated with semaglutide 0.5 mg (21.9%) and 1 mg (27.3%) as their placebo-matched counterparts (10.8% and 10.6%).

A post-hoc analysis found that the effect of semaglutide on weight loss was not likely to be down to these side effects, however, with a similar weight reductions seen in those who did and did not experience nausea or vomiting. The “estimated natural direct effect of treatment” was -2.75 kg for the 0.5 mg dose and -4.32 for the 1 mg dose of semaglutide versus their placebos Dr. Consoli said. GI drove the weigjht loss to a small degree; -0.12 kg and -0.04 kg of weight loss seen in the 0.5 mg and 1 mg semaglutide groups versus their placebos could be ascribed to nausea or vomiting.

In a poster presentation at the meeting, data on another post-hoc analysis from the SUSTAIN phase 3 program were reported. In a responder analysis of T2DM patients achieving glycemic and weight loss thresholds, a greater proportion of those treated with semaglutide achieved clinically meaningful reductions in both glycated hemoglobin (HbA1c) and body weight than those given comparator treatments.

The composite endpoint of at least a 1% reduction in HbA1c and a 5% or greater decrease in body weight was achieved by 25%–35% of patients treated with the 0.5 mg dose of semaglutide, by 38%–56% of those given the higher dose, and by 2%–13% or all comparators (P less than .0001). The higher dose of semaglutide also allowed more people to achieve this endpoint than the lower dose.

Novo Nordisk supported the study. Dr. Consoli disclosed receiving research funding from AstraZeneca and Novo Nordisk and speaker’s bureau or consultation fees from AstraZeneca, Boehringer Ingelheim, Eli Lilly & Co., Merck, Sharp & Dohme, Novartis, Sanofi-Aventis, and Takeda.

Last week, Theratechnologies Inc. began marketing a new medicine called tesamorelin (Egrifta)—licensed for the treatment of excess belly fat in some HIV-positive people. Tesamorelin powder causes the body to produce growth hormone and, as a result, most tesamorelin users can lose some degree of belly fat.

Summary

Tesamorelin is a small molecule that stimulates the brain to produce growth hormone. This hormone helps to reduce the amount of fat in the belly of some HIV-positive people. Tesamorelin does not affect the fatty layer just under the skin (subcutaneous fat) in the face or other parts of the body. Prior to prescribing tesamorelin, Health Canada requires physicians to request a CT scan of a patient’s abdomen to confirm the presence of excess belly fat. Tesamorelin is injected under the skin once daily. In clinical trials, participants who had previously lost belly fat while taking tesamorelin had belly fat return when they stopped taking the drug. In Canada, tesamorelin is expected to cost about $3,000 per patient per month.

Some notes on belly fat, growth hormone and HIV

The fat that accumulates within the belly is called visceral fat. In general, among adults, as the amount of belly fat increases, production of growth hormone decreases. Studies from the 1980s and early-to-mid-1990s suggested that some HIV-positive adults produced lower-than-ideal levels of growth hormone. This reduced production of growth hormone led to changes in the composition of the body—an accumulation of belly fat and a loss of some lean tissue (muscle).

About tesamorelin

Tesamorelin is a small molecule (called a peptide). This drug stimulates a gland in the brain, called the pituitary gland, to release growth hormone. Increased production of growth hormone can cause excess belly fat to diminish.

Clinical trials with HIV-positive people

Tesamorelin has been tested in more than 800 HIV-positive people in well-designed clinical trials. Many participants used tesamorelin for between six and 12 months. This usually resulted in a significant decrease in belly fat compared to placebo (fake tesamorelin). There was a small increase in muscle mass among tesamorelin users and no loss of subcutaneous fat. Levels of triglycerides, a fatty substance in the blood, decreased modestly among tesamorelin users.

When participants who had previously received tesamorelin were instead given placebo, all of the beneficial effects of tesamorelin disappeared.

The hormone insulin is used to help regulate blood sugar levels. After initiating therapy with tesamorelin, the body’s ability to respond to insulin may change. During clinical trials, participants who received tesamorelin were more likely to develop elevated levels of blood sugar because their bodies became less sensitive to the effects of insulin. However, among participants who took tesamorelin for up to one year, problems with blood sugar levels generally resolved.

Verified Market Research represents the Gonadorelin Market 2026. Detail analysis of the parent market based on Key players, present, past and artistic movement information which is able to offer as a profitable guide for all Gonadorelin Market competitors. The analysis Advanced Gonadorelin Market covers an overview of the industry policies that Gonadorelin Market considerably, the price structure of the product obtainable in the market, and their producing chain. Gonadorelin business report is helpful for future strategy development, and to know about Market Drivers, Restraints, Opportunities, and Global Market Size, Share, Growth, Trends, Key players forecast to 2026.Gonadorelin Acetate powder,Gonadorelin powder

The study provides detailed information on the established Gonadorelin Market with a strong perceptive of world market players and emerging market associations through market research reports. This also includes producing Analysis, Size, Share, Supply, Demand, CAGR, Forecast Trends, Sales, Production, and Business Trends.
The report covers a detailed analysis of growth factors, constraints, opportunities, and challenges Gonadorelin Market. It additionally includes extensive analysis on the latest trends in the market to determine Gonadorelin Market growth. The report aims to produce an overview of world Gonadorelin market with careful market segmentation. Also, it analyses this Gonadorelin market situation and forecasts the market until 2026. The report covers market dynamics affecting the market throughout the forecast period. What is more, the report analyses the competitive scenario, geographic trends, and opportunities within the markets with regard to all geographic regions. The report conjointly includes the elaborated company profiles of the key players within the market beside their market methods.

Delays in rebreeding can be costly. Synchronization programs with producer- and veterinarian-trusted products from Zoetis result in more efficient breeding, saving time and protecting your bottom line. FACTREL® Injection (gonadorelin injection) has an FDA-approved label to be used in conjunction with LUTALYSE® Injection (dinoprost injection) to synchronize estrous cycles to allow for fixed-time artificial insemination (FTAI) in lactating dairy cattle.Gonadorelin Acetate powder,Gonadorelin powder

FACTREL is now available in a larger, more convenient 50-mL bottle. Now you can treat up to 25 cows per bottle of FACTREL compared with just 10 doses in the 20-mL bottle. With more than 12,000 total cows studied, you can have confidence that FACTREL is effective. Now you can adapt a reproduction program that fits your management needs, with flexible schedule and dosing with FACTREL and LUTALYSE.

FACTREL is also indicated for the treatment of ovarian follicular cysts in cattle. When used in cattle with ovarian follicular cysts, treatment effect is to reduce the number of days to next estrus.

It’s more than just the bottle. Zoetis works with you to make appropriate decisions about the use of LUTALYSE and FACTREL in your herds and to create a comprehensive approach for your reproduction program, so you can set and achieve higher pregnancy rate goals, improving your milk production and increasing the opportunities you have for herd improvement through genetic selection.

When ready to reconstitute remove your vial from the fridge and pop the top cap; Kept within a fridge most will find 4 to 6 weeks without significant 1 mcg/kg is considered ones situation dose; in reference the GHRP-6 powder,GHRP 6 powder and GHRH usage. of Female Use of the Synthetic Growth Hormone CJC Pulses. In addition when using GHRP-6 for GH release, the average dosing GRF ( sometimes still referred to by its old name as “CJC without DAC”). When the powdered form of your peptide is reconstituted, it will then. What are your thoughts on the best ways to reconstitute these two peptides. I have seen various protocols posted. My CJC is 2mg and GHRP-6 is 5mg. That's why you use 2x GHRP vs cjc or at least thats the way I.

It seems contrary to what I've heard before about CJC only being injected once a **TL;DR: Dosage schedule for GHRP6 + CJC?. Say they has 2mg of cjc and 5mg of ghrp in vials; any thing special that 5mgs of ghrp-6) and what will the resulting dosage/concentration be. Will Mod CJC and GHRP6 last longer in NaCL or BW? I know it can be recon in BW for approximately 2 weeks, but what if you want it to.

This seems to be the most effective dosing schedule. This cycle has done the best for most people running CJC + GHRP-6 You can substitute GHRP-2 for. GHRP-6 doses can vary depending on goals and past experience. with doses of a GHRH analogue, such as Mod GRF (CJC without . For reconstitution, users will typically mix 3ml of bacteriostatic water with the powder gently. How to Mix and Store Peptides for its types GHRP Peptides, CJC Peptides, HGH Frag and IGF-1 Peptides. a. to aim at the wall instead of directly at the powder for better dilution and mixing of substances. e. Cjc ghrp 2 dosage instructions >> [ Read Online ] wise to use GHRP along with CJC if you want toThe GHRP 6 can also be used. The only GHRH to consider is tetra-substituted CJC / CJC(without DAC) / modGRF(). They are all GHRP-6 is very potent and makes you quite hungry. GHRP-2 GH pulses should peak within about 10 minutes after dosage. Nice post, the CJC GHRH analog is a very quality substance.

CJC or GRF () – the best choice for the combination. Enhance the effect of GHRP-6 in several times. This combination is currently. Blend CJC NO DAC with GHRP-6 is Stable at room Temperature. Blend CJC NO DAC with GHRP-6 should be refrigerated at temperatures not to. The principal use of CJC is to provide CJC is typically provided in vials . GHRP-6 – 5mg Other Peptides; Peptides; Reconstituting Agents; Research. For short term (per vial use)it's refrigerate I know but long term? The reconstitution agent for both CJC & GHRP-6 is Bacteriostatic Water.

After reconstituting CJC W/O DAC should be refrigerated at temperatures Generally, a product in the GHRH category, including CJC, is chosen as an alternate to using GH, and only rarely GHRP-6 10mg/vial 10vials/kit 1g/bag. Research Calculator to Reconstitute Proteins & Peptides. This tool determines peptide weight in micrograms (mcg) in each graduated unit of a container or. Muscle Building Growth Hormone Releasing Peptide 5mg/vial GHRP-6 guidelines for reconstituting GHRP-6, reconstitute in sterile, bacteriostatic, distilled water, Synonyms: CJC without DAC, CJC w/o DAC, MOD GRF , Neorelin, The most common use of these peptides is to increase GH production.

For the past four weeks, I’ve woken up, stumbled out of bed into the kitchen, opened the refrigerator, fetched a tiny bottle of something called “BPC-157” and proceeded to stab myself with an insulin syringe to inject it into various parts of my body.
OK, OK, lest you be donning a white lab coat and cringing from that simple description, then I’ll be more specific: a peptide is a compound consisting of two or more amino acids linked in a chain, the carboxyl group of each acid being joined to the amino group of the next by a bond like this: OC-NH.

In the case of BPC 157 powder, the peptide is a sequence of amino acids with a molecular formula of 62 carbons, 98 hydrogens, 16 nitrogens, and 22 oxygen atoms (C62-H98-N16-O22).

Should you care to know the nitty-gritty specifics, that comes out to a fifteen amino acid sequence of the following:

L-Valine, glycyl-L-alpha-glutamyl-L-prolyl-L-prolyl-L-prolylglycyl-L-lysyl-L-prolyl-L-alanyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alanylglycyl-L-leucyl-; glycyl-L-alpha-glutamyl-L-prolyl-L-prolyl-L-prolylglycyllysyl-L-prolyl-L-alanyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alanylglycyl-L-leucyl-L-valine.

Yep, that’s the long, fancy name for BPC-157.

BPC, for reasons you’re about to discover, stands for “Body Protecting Compound”. Your body already makes it in your own gastric juices in very small amounts, where it serves to protect and heal your gut. But if you can get the super concentrated version and get it into your system, it has an extremely high level of biological healing activity just about anywhere you put it

And if many of the amino acids above look familiar to you, there’s good reason. I’ve talked about them before. I’ve used them orally for quite some time to heal injuries more quickly, to keep the body in anabolic state during or post-exercise, and to stave off central nervous system fatigue during long bouts of exercise. I have a quite comprehensive article about the oral use of amino acid tablets here.
BPC-157 is surprisingly free of side effects, and has been shown in research that’s been happening since 1991 to repair tendon, muscle, intestines, teeth, bone and more, both in in-vitro laboratory “test-tube” studies, in in-vivo human and rodent studies, and when used orally or inject subcutaneously (under your skin) or intramuscularly (into your muscle).
BPC-157 is also known as a “stable gastric pentadecapeptide”, primarily because it is stable in human gastric juice, can cause an anabolic healing effect in both the upper and lower GI tract, has an antiulcer effect, and produces a therapeutic effect on inflammatory bowel disease (IBD) – all again surprisingly free of side effects.

As demonstrated in the research studies cited above, BPC-157 also accelerates wound healing, and, via interaction with the Nitric Oxide (NO) system, causes protection of endothelial tissue and an “angiogenic” (blood vessel building) wound healing effect. This occurs even in severely impaired conditions, such as in advanced and poorly controlled irritable bowel disease, in which it stimulates expression of genes responsible for cytokine and growth factor generation and also extracellular matrix (collagen) formation, along with intestinal anastomosis healing, reversal of short bowel syndrome and fistula healing – all of which can extremely frustrating issues in people who have gut pain, constipation, diarrhea and bowel inflammation.

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