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How to Clear Cookies in Firefox
In Firefox, Cookies are stored in a single file on your computer by websites you visit and contain information such as site preferences or login status. But cookies can be harmful.
As we’ve talked about what cookies are and how to clear cookies in Chrome, today we are going to tell you how to delete cookies in Firefox.
How to clear cookies in Firefox on your Windows or Mac computer
1. Open Firefox
2. Open menu in the upper right corner of the browser
3. Select “Options”
4. Click “Privacy & Security”
5. Scroll down to the section “Cookies and Site Data”
6. Tap “Clear Data” to clear all cookies and site data stored by Firefox
Note: Clearing all cookies and site data stored by Firefox may sign you out of websites and remove offline web content. Clearing cache data will not affect your logins.VPN download
How to clear cookies in Firefox on your Android device
1. Open Firefox app
2. Tap “Menu” at the top right
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How to clear cookies in Firefox on your iOS device
1. Open Firefox app
2. Tap the menu button at the bottom of the screen (the menu will be at the top right if you’re using an iPad)
3. Tap “Settings”
4. Tap “Clear Private Data”
On the “Clear Private Data” screen, make sure the “Cookies” slider button is on. Turn on other options as desired. Then, tap “Clear Private Data”.
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Ryan Mason used to play for Tottenham Hotspur and Hull before he was forced to retire in February 2018.It was after he fractured his skull during a challenge in a Premier League game over a year earlier.Children football in Shanghai

"I look at some kids and they head the ball with the top of the head and their technique is all wrong, therefore the pressure that it's putting on the brain is a lot more. I don't think kids should be heading real balls." he said."Maybe bring in sponge balls to learn the technique and gain that experience of actually challenging for a header."

He wants the ban to better protect kids from head injuries.The Professional Footballers' Association (PFA) has also previously called for restrictions on young players until more is known about the long-term health risks of heading.

One of the world's leading experts on brain injuries, Dr Bennet Omalu, said last year that he thought heading a football should be restricted in the professional game and banned for under 18s.One of the big arguments for the ban is a type of head injury that football players can suffer called 'concussion'.

It happens when someone gets a significant bang on the head - so much that the brain is shaken and knocks against the inside of the skull.

This causes the nerves and structures in the brain to be altered, which means messages aren't sent around the brain in the right way.It can be serious and it might take someone several days to recover if they have a very bad bang to the head.Some people think that in order to get concussion, you have to be knocked unconscious - but that isn't true.One of the big issues. is that we don't know how heading footballs impacts on someone's health.

A lot of people think more research needs to be done to know the long-term risks.The Football Association says it is "committed to researching and examining all areas" of head injuries in the game, including the long-term effects on players.

An FA spokesperson said: "We have commissioned comprehensive and rigorous research studies in this area, in collaboration with the Drake Foundation and the PFA, which are currently ongoing."These studies will help establish whether or not there are any risks associated with playing football."
Bath Spa University is offering the next generation of budding primary school teachers an alternative route into an exceptional teaching career with the launch of its new part-time primary PGCE course.

Bath Spa’s Institute for Education, which has been training teachers and other education professionals since 1946, has launched the course to widen access to teaching.

The innovative new programme opens doors to career changers, who will benefit from continuing to earn an income while studying, as well as to those who may not be able to train to become teachers through a traditional full-time programme.

The 16-month course, which starts at the end of January 2019, responds to recent changes in government funding for primary initial teacher training and will alleviate some of the financial pressure associated with studying to become a teacher.

Bath Spa University is also offering a £500 scholarship to part-time primary PGCE students to thank them for choosing a career in teaching.

Pat Black, Head of Initial Teacher Education at Bath Spa University, said: “Primary school education is so critical for the development of our children’s thinking and learning so we want to ensure they have exceptional teachers to support them. However, the climate for primary schools and their teachers is changing, with many feeling the pressure of funding and bursary cuts which can discourage them from considering what can be an incredibly inspiring and rewarding career. We wanted to do something positive to overcome this and help attract the next generation of talent.

“Our new part-time programme opens doors that would otherwise be closed to some applicants so we’re encouraging anyone who’s thinking about a career in primary school teaching, whether they’re straight out of university or considering a career change, to apply for the course which they can complete around their everyday life.”

The part-time Primary PGCE course, which begins on 21 January 2019, is open to those with an undergraduate degree in any subject and GCSEs (grade C or above) in English, Maths and Science. Training is for three days per week until the final 10-week full-time placement.

This unique timetable will be delivered as part of Bath Spa University’s ‘outstanding’ teacher training programme as rated by Ofsted.
It’s been detecting what are known as ‘FRBs’ (Fast Radio Bursts) which are small pulses of radio waves originating out in the cosmos. The source of the signals is unknown but they are believed to be coming from a region of space around three billion light years from Earth. The 500-meter fixed diameter Aperture Spherical Radio Telescope, nicknamed Tianyan, is located Guizhou, southwest China. Officials say it’s picked up over 100 FRBs since late August, all coming from this same source – designated FRB121102. Experts at the Chinese Academy of Sciences are currently analysing and cross-checking these signals to try and understand more about where they come from. It’s currently believed that FSBs are created by certain processes out in deep space, rather than from any kind of alien technology.To get more chinese online news, you can visit shine news official website.

Most are ‘one-offs” but a small amount are ‘repeaters’ which recur in the same place. One prevailing theory is the radio bursts are a side effect of neutron stars colliding with black holes. Another suggests they are produced by so-called ‘magnetars’ – neutron stars with incredibly powerful magnetic fields. But that was called into question back in July when a new burst was picked up and attributed to a spiral galaxy 7.9 billion light years away that resembles our own Milky Way. A team of stargazers used the Australian Square Kilometer Array to pinpoint the origins of a burst called FRB 190523. ‘This finding tells us that every galaxy, even a run-of-the-mill galaxy like our Milky Way, can generate an FRB,’ said Vikram Ravi, assistant professor of astronomy at Caltech. ‘Finding the locations of the one-off FRBs is challenging because it requires a radio telescope that can both discover these extremely short events and locate them with the resolving power of a mile-wide radio dish.’ ‘The theory that FRBs come from magnetars was developed in part because the earlier FRB 121102 came from an active star-forming environment, where young magnetars can be formed in the supernovae of massive stars,’ added Ravi. ‘But the host galaxy of FRB 190523 is more mellow in comparison.’

If ever there was going to be a telescope that uncovered the mystery of FRBs it would be China’s new radio telescope – it’s the largest and most sensitive radio observatory ever constructed. The telescope’s considerable observational power will be used by astronomers from various nations to study such phenomena as exoplanets, gravitational waves and ultra-high-energy cosmic rays. However, the addition of a highly-sensitive secondary system to the giant telescope has enabled it to detect fast radio bursts with high efficiency and in real time at the same time as undertaking over observation tasks. It is expected that Tianyan will allow researchers to pinpoint the origins of these mysterious pulses with significantly greater accuracy.
He co-founded Alibaba in 1999 and it has become one of the world's biggest internet firms.Mr Ma's success and colourful style has made him one of China's most recognisable businessmen.To get more china news online, you can visit shine news official website.
Daniel Zhang, currently Alibaba's chief executive, will replace him as executive chairman.The company is now valued at $480bn (£389bn) and Mr Ma is China's richest man, with a net worth of $38.6bn according to Forbes.
He is also the first founder among a generation of prominent Chinese internet entrepreneurs to step down from his company."I think it will be very hard to replace somebody like Jack Ma," said Rebecca Fannin, author of a book on China's technology titans.Born to a poor family in the eastern Chinese city of Hangzhou, Mr Ma began his career as an teacher.
He bought his first computer at the age of 33 and was surprised when no Chinese beers turned up in his first online search for "beer".
With no background in computing, Mr Ma co-founded Alibaba in his apartment, having convinced a group of friends to invest in his online marketplace.
It was not the first time he had tried to get a start-up off the ground.
"Alibaba was his third attempt at a company, he had two trials before," said Duncan Clark who has written a book about Mr Ma and is also chairman of investment consultancy BDA China.
"He saw the promise of the internet quite early on, but it took a while for him to have a vehicle."Over the years, Alibaba has grown from an online marketplace into an e-commerce giant with interests ranging from financial services to artificial intelligence.
It was originally set up as a trading platform for businesses, before expanding into consumer e-commerce in 2003 and later launching digital payment platform Alipay.
Lacking a background in technology and with no particular strength in finance, Mr Clark said charisma and strategic vision have been Mr Ma's biggest assets.
"His charm is a big part of his leadership, his ability to convince people whether it's customers, employees or critically shareholders."
The author first met Mr Ma two decades ago and the entrepreneur spoke of making Alibaba one of the top 10 internet companies in the world within a decade.
"[It was] a sort of impossible ambition in a way but somehow he made people believe it," Mr Clark said.Earlier this year, he argued in favour of the "996 system" where workers are expected to work 12 hour days, and a six-day week - a hotly debated topic in Chinese media.
The flamboyant businessman is also known for enjoying the limelight and featured at an Alibaba event in 2017 wearing a Michael Jackson-themed outfit.Quiet, unassuming and known to shy away from the spotlight, Mr Zhang is nothing like his predecessor.
Inside Alibaba Mr Zhang is reportedly known as Xiaoyaozi, the name of a character in a Chinese martial arts novel. It means the "unfettered one"- someone who stays out of battles but is great at training others.
That reputation will come in handy as he steers Alibaba through arguably some of its most challenging times. The Chinese market, where it makes two thirds of its revenue, is slowing down.
At the same time, attempts to expand internationally have struggled.
US scrutiny of Chinese firms is blocking its growth in the West. In parts of South East Asia and India, analysts say understanding how to work in local markets and with local people is proving to be a challenge for the Chinese company.
Then there's the delayed multi-billion dollar public offering in Hong Kong, reportedly due to pro-democracy protests there.
Yet Mr Zhang's greatest challenge may be living up to the image of Mr Ma himself, a man who enjoyed the respect and affection of his staff as well as the international community.
Raw Steroid Powder Superdrols for Musle Mass

Superdrol powder for sale is a very powerful supplement. In as little as 10 days, those on Superdrols will notice large increases in strength. Superdrols is an anabolic substance, meaning it promotes protein synthesis, and thus muscle strength. When muscles become stronger, they grow. Ultimately, Superdrols users experience large gains in muscle mass because their muscles become much stronger.

Superdrols also shortens recovery time. This means those on Superdrols can lift weights faster after their last workout than would normally be the case. It is almost impossible to overtrain while taking Superdrols, and more time in the gym equals more muscle mass. In addition, Superdrols also increases the length and quality of workouts. Rest time between sets is diminished because muscles do not need as much time as normal to recover. With more workouts that are longer and more efficient, it is rather easy to see how Superdrols can help someone achieve more lean muscle.

Superdrols Ettect

It is an anabolic substance, meaning it promotes protein synthesis, and thus muscle strength. When muscles become stronger, they grow. Ultimately, Superdrols users experience large gains in muscle mass because their muscles become much stronger.

Another advantage to using Superdrols is that it does not turn into estrogen. Many prohormones available start out as a substance in the body, but then eventually turn into estrogen through a process called aromatization. Estrogen causes decreased strength, muscle loss and fat gain. Thus, it is a promoter of the exact opposite traits someone who is taking Superdrols would want. These characteristics arise after one stops taking the compound. With Superdrols, however, the aromatization process never starts. The compound does not turn into estrogen in the body, meaning much of the muscle gain and fat loss one experienced while taking it will remain after dosing concludes.

Superdrols Dosage and Stacks

The recommended use for this product is about 20mg to 40mg per day, depending on goals. With the cycle not being any longer than 6 weeks. Superdrols has been widely reported as being abused, with guys staying on cycle as long as 12 weeks, with devastating results on their liver functions.

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Buy Superdrol powder is a revolutionary prohormone with Cyclosome Delivery, the most advanced delivery method on the market today. Whether you are a serious bodybuilder or an everyday gym enthusiast, Hi-Tech Pharma Superdrol can be the perfect supplement for you to build the physique you want. Dramatically increase size and strength, plus increase muscle hardness and density with Superdrol.

Note: Manufacturers continually change product specifications. While we try our best to keep product descriptions up to date, they do not necessarily reflect the latest information available from the manufacturer. We are not responsible for incorrect or outdated product descriptions and/or images.

FDA: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

We are one of the innovative and high-tech company in steroid hormone fields in China, who has engaged in R&D, production and marketing for more than 10 years. Mainly for high quality steroids raw powder,semi-finished oils,HGH,SARMS and Peptide,Buy Proviron powder in bulk

Every batch of raws must do HPLC test and only quality raws are allowed to sell to customers. If you are interested in steroid powders,welcome to email us for more.Provironused by those who have had a poor reaction to testosterone treatments. The drug has shown to be beneficial in treating sexual dysfunction, impotency and low libido. Mesterolone binds to estrogen receptors, reducing their activity, which not only reduces estrogen production, but also encourages natural testosterone production in the body.
Proviron is awesome! I recommend it for sure.I’m pleased with results and always incorporate Proviron into my cycles or in between cycles. –Matt
Business details

We use HKEMS,EMS, Fedex, EUB and so on to deliver the goods, the clearance rate is very high and it’s safe, fast.
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Chemical name: 1alpha-Methylandrostan-17beta-ol-3-one
Synonyms: Buy Proviron powder; Proviron; Oral Proviron powder;17beta-Hydroxy-1alpha-methyl-5alpha-androstan-3-one;
CAS: 1424-00-6
EINECS: 215-836-3
Molecular Formula: C20H32O2
Molecular weight: 304.47
Packing: 1kg Aluminum foil bags
Shipping:Express Courier
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Payment term:Western Union;Moneygram;Bank wire;Bitcoin
Appearance: White crystalline powder.
Usage: Pharmaceutical material, Steroid hormone, Anabolin. Male hormone drugs for male sexual dysfunction, aplastic anemia. Proviron is often used as an antiestrogenic treatment and may be used by those who have had a poor reaction to testosterone treatments. The drug has shown to be beneficial in treating sexual dysfunction, impotency and low libido.Proviron binds to estrogen receptors, reducing their activity, which not only reduces estrogen production, but also encourages natural testosterone production in the body.

Effective Dose: 25-200mgs/day
Active Life: up to 12 hours
Detection Time: 5-6weeks
Androgenic: Anabolic Ratio:30-40/100-150

1-Testosterone Cypionate Dihydroboldenone Anabolic Powder

1-Testosterone Cypionate is a relatively new AAS product on the market, which is vastly increasing in popularity. However, since the demand of this product outweighs the supply, there is a lack of reputable reviews on this products performance, post injection pain (PIP) and suitability for AAS users who are looking to adapt their aesthetics in an uncommon/unconventional manner. So, in order to increase the knowledge available for this product (1-Testosterone Cypionate) I have created a review based upon my personal pinning experiences.Dihydroboldenone/DHB powder for sale
1-Testosterone Cypionate Powder Applications:
It is a kind of estrogen, can promote and regulate the normal development of women’s genitals and secondary. Can cause hyperplasia of mammary gland carcinoma development, but in larger doses, can inhibit pituitary prolactin release, and reduce the secretion of milk. Potent mammalian estrogenic hormone produced by the ovary.

It is a potent androgen with anabolic properties. Since the begining of the year 2005, the use of steroid precursors (prohormones) is illegal in the United States.Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Steroid and Hormone.


The ideal DHB dosage ranges from 300 to 400mg per week for male users. The drug can also be used by female athletes but in low dosages. For the female athletes, it’s advisable to start with very low dosages to avoid adverse side effects such as virilization. Dosage for female athletes should be between 25 to 100mgs per week. However, for the females with zero experience with anabolic steroids, the dosage can be lowered by the doctor, and then be increased later after finishing the beginner cycle. The same also applies to men; beginners should avoid high dihydroboldenone dosages and always consult a doctor before increasing the doses.

Typical cycle:

Users will usually kickstart their cycle off with an oral and then stack around 400-500 milligrams

(mg) per week of DHB with some long estered testosterone. When you do this, you should also

run an aromatase inhibitor (AI) to offset the estrogen increases from testosterone, and you should

also use such support supplements.

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Raw 1-Testosterone (Dihydroboldenone) powder or DHB for short, is an anabolic steroid that differs from testosterone by having a 1,2-double bond instead of a 4,5-double bond in its A ring. A potent androgen with anabolic properties, The reason it is so popular among bodybuilders and fitness enthusiasts is the fact that it has some truly unique properties. It is actually a type derived from the synthetic anabolic steroid Boldenone, which is androgenic in nature. It tries to mimic the effects of testosterone. As it is a metabolite of Boldenone itself, it is also referred to as 4-Dihydroboldenone, besides DHB and 1-testerone. it was legally sold as a prohormone in the U.S.A. until 2005, when it was reclassified as a Schedule III drug. It has a role as an anabolic agent. It is an anabolic androgenic steroid, a 17beta-hydroxy steroid and a 3-oxo-Delta(1) steroid.This product is intended for research and forensic applications.Dihydroboldenone/DHB powder

1-Testosterone powder (dihydroboldenone powder), or DHB powder for short, is an anabolic steroid delivers quality results especially to bodybuilders, runners, and cyclists. Interestingly, in spite of the fact that the name can be confusing, in no way is DHB testosterone. In fact, it is simply the 5alpha reduced form of Equipoise (boldenone), which acts in a completely different way. Therefore, DHB great anabolic strength feature enables the steroid to deliver reliable and positive effects with fewer side effects. Potency and power combined with reduced estrogenic effects are the initial advantages of incorporating.

DTH powder is a natural hormone that occurs in your body after testosterone conversion. Just like some steroids which once in the body system convert into DTH and DHB, testosterone converts into estrogen and DTH. The drug has minimal side effects which makes it ideal for many professional bodybuilders. Dihydroboldenone powder is highly anabolic meaning it’s capable of providing great lean muscles to its users. The drug doesn’t increase water retention in the muscles and has zero aromatizing effects. Depending on your level of usage, the doctor should guide you in determining the right dosage. To be safe, a medical examination should be undertaken before and after completing the first cycle. Human bodies react differently to drugs more so the steroids, and therefore close medical supervision is essential for better results.

It is best to start out with at least a week at a dose of 5-10 mg to see how one reacts. Many users find this range to be effective, while others feel the ideal amount is 20-40 mg. It comes down to the experience, goals, and individual reaction. Many find a lower dose to be just as effective as a higher one, but with less side effects. With a compound such as this,it is generally best to err on the side of caution,especially for those that are less experienced with steroids. Most seem to find their ideal dose to be in the 10-30 mg range. Cycle length should be kept short,in the range of 1-4 weeks.Finally, it is especially important to take adequate time off after each cycle with this substance to allow the body to recover.
tem Name:Gonadorelin Acetate powder,Gonadorelin powder
Molecular Formula: C55H75N17O13
CAS No.: 71447-49-9
Description of Gonadorelin Acetate:
Appearance: White powder
Specific Optical Rotation [a]eq \o(\s\up 6
(20),\s\do 2( D))20 D(c=1,1% HAc): -55.0~-65.0°
Water Content(Karl Fischer): ≤8.0%
Acetate Content(by HPLC): ≤10.0%
Amino Acid Composition: ±10% of theoretical
Purity (by HPLC): ≥98.0%
Single Impurity(by HPLC): ≤1.0%
Peptide Content(by %N): ≥80%
Assay(By Anhydrous, Acetic Acid-free ): 95.0~105.0%
Becterial Endotoxins: ≤5EU/mg
Gonadotropin-releasing hormone (GnRH) is considered a neurohormone, a hormone produced in a specific neural cell and released at its neural terminal. A key area for production of GNRH is the preoptic area of the hypothalamus, which contains most of the GnRH-secreting neurons. GnRH neurons originate in the nose and migrate into the brain, where they are scattered throughout the medial septum and hypothalamus and connected by very long >1-millimeter-long dendrites. These bundle together so they receive shared synaptic input, a process that allows them to synchronize their GnRH release.
The GHRP-6 powder,GHRP 6 powder is enclosed in an antivirus capsule, which essentially the outer capsule of a virus that contains no actual viral DNA or RNA so it is completely safe. The Antivirus used has been engineered to contain special peptides on it that actually act like an adhesive glue to certain cells in your mouth. These peptides are very important because by adhering to the mucosal cells in your mouth they ensure that the antivirus can inject the GHRP6 into your cells. The antivirus signals the lipid membrane to open protein channels that actually take the peptide into the cell.
The peptide is now free to be release through the lymphatic system in its biological active form. This means it is carried throughout the blood stream directly from the cells in your mouth. So there is no sudden spike of GHRP6 your own cells actually regulate its release. It never reaches any digestive enzymes or acids beyond that of the mucus in your moth which is actually at about the same pH used to store GHRP-6 in acetic acid, so claiming that it?s broken down here is ridiculous. The transport of the peptide to the lymphatic system is what results in a slower more controlled release of the peptide over time.
Users are instructed not to take this product with food, because this will also greatly hinder the amount of the item that is actually absorbed by the body. It is also important to note that users shouldn’t brush their teeth or do any kind of mouthwash 30 minutes before or after administration. The basic idea is to keep the mouth as undisturbed and as dry as possible while the hormone has time to seep into the pours on the inner lining of the mouth so that it can be properly absorbed.

Galvalume Steel Roll Bpc 157

BPC 157 powder Overview
Quick Details
CAS No.:
Other Names:
bpc 157
C141h235n47o41, C141h235n47o41
Place of Origin:
Jiangsu, China (Mainland)
Auxiliaries and Other Medicinal Chemicals
Grade Standard:
Medicine Grade
Animal Pharmaceuticals
Brand Name:
Model Number:
Product Name:
bpc 157
White powder
Cosmetic Raw Materials
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Packaging Details

1. A sealed vial or cartridge containing a storage stable pharmaceutical composition in the form of a sterile solution ready for parenteral administration in an human patient, which solution comprises PTH(1-34), a buffer to maintain a pH from 3 to 7 and a polyol stabilizing agent, and which solution has not been reconstituted from a lyophilisate."Teriparatide Acetate powder

"19. A process for preparing a pharmaceutical composition in the form of a sterile solution ready for parenteral administration, said process comprising: mixing human PTH(1-34), a buffering agent and an excipient to form an aqueous solution containing PTH in a concentration range from 25myg/mL to 1000myg/mL, which is then sterile-filtered and filled into a vial or cartridge for use, wherein the excipient comprises a polyol stabilising agent".

"30. A pharmaceutical composition in the form of a stabilized solution comprising: (a) a therapeutically effective amount of human PTH(1-34); (b) an effective amount of a polyol stabilizing agent; (c) a buffering agent in an amount sufficient to maintain the pH of the composition within a range of about 3-7; (d) a parenterally acceptable preservative; and (e) the balance bing water."

II. Four oppositions were filed against the granted patent under Article 100(a), (b) and (c) EPC on the grounds that its subject-matter lacked novelty and inventive step, the patent was not sufficiently disclosed, and its subject-matter extended beyond the content of the application as filed.

III. The appeal by the opponents OP1, OP2 and OP3 (hereinafter appellants 01, 02 and 03) lies from the decision of the opposition division that the patent in amended form based on auxiliary request 19 filed during oral proceedings met the requirements of the EPC.
V. According to the decision under appeal, the main request comprised subject-matter extending beyond the content of the original and parent applications contrary to Articles 123(2) EPC and 76(1) EPC. Auxiliary requests 1-7 did not comply with the requirements of Article 123(3) EPC. Auxiliary requests 8-17 did not meet the requirements of Articles 76(1) and 123(2) EPC. Auxiliary request 18 was not admitted into the opposition proceedings under Rule 80 EPC.

In auxiliary request 19, claims 1-18 and 31 had been deleted, and the requirements of Articles 123(3), Art. 84, A76(1) and 123(2) EPC and Rule 80 EPC were met by this request.

Process claim 1 corresponded to claim 19 as granted with the further feature "and wherein said composition further comprises a parenterally acceptable preservative". Product claim 11 was identical to claim 30 as granted.

The subject-matte of the claims of auxiliary request 19 was considered to be new inter alia over D1.

As regards inventive step, D21 was considered to represent the closest prior art; it related to the problem of stabilizing PTH, and PTH(1-34) was mentioned. The formulations according to D21 contained PTH with a basic amino acid such as arginine, in particular for injection or infusion with a pH of 4-8.

D1 and D2 could not be considered as an appropriate starting point, since these documents did not specifically relate to human PTH(1-34). D12 related to human PTH(1-34) but did not refer to a buffer or preservative and did not recognize any particular stability of the disclosed formulations. Neither did D39 and D41 recognized any particular stability associated with the disclosed compositions.

The difference between D21 and the claimed subject-matter concerned the presence of a buffer in combination with a polyol and the addition of a parenterally acceptable preservative as defined in the contested claims. The problem to be solved in the light of D21 was the provision of an alternative stable liquid formulation of human PTH(1-34), which was ready for administration and suitable for use as a multi-dose formulation. The claimed subject-matter was not considered obvious to the skilled person from D21.

VI. With its statement of the grounds of appeal dated 2 November 2016, appellant 03 requested an accelerated appeal proceedings.

VII. With a letter dated 28 March 2017, the patent proprietor (hereafter the respondent) filed a main request (corresponding to auxiliary request 19 maintained by the opposition division) and auxiliary requests 1-20.

The subject-matter of claim 1 of the main request corresponded to claim 19 as granted with the further specification "and wherein said composition further comprises a parenterally acceptable preservative". The product claim 11 was identical to claim 30 as granted.

VIII. A communication from the Board was sent to the parties. The Board mentioned in particular that documents D41 and D2 appeared to be as closer on a technical point of view to the claimed invention than D1 or D21, and that these documents could be the closest prior art for assessing inventive step
Pfenex announced this week that it submitted to the FDA a New Drug Application (NDA) for its PF708, a Teriparatide Acetate powder follow-on referencing Eli Lilly’s Forteo for the treatment of osteoporosis.

“We are pleased to submit to the FDA an NDA for PF708 as a proposed therapeutic equivalent to Forteo, which achieved $1.7 billion in global sales in 2017,” Eef Schimmelpennink, CEO of Pfenex, said in a statement announcing the submission. Schimmelpennink added that the timing of the submission could allow for a commercial launch of the follow-on as early as the fourth quarter of 2019, should the FDA approve the product.

The data package for PF708 includes data from a 24-week study in 181 patients with osteoporosis, results of which were announced earlier this year. The primary end point of the study was incidence of antidrug antibodies (ADAs) at week 24, and secondary end points included the mean percentage changes in lumbar-spine bone mineral density (BMD) and median percentage changes in bone turnover markers after week 24, as well as pharmacokinetic parameters for up to 4 hours after the first dose.

In total, 2 patients in the PF708 arm and 2 patients in the reference arm developed ADAs during the study period. The follow-on and reference teriparatide demonstrated comparable effects, with no statistically significant differences observed, on lumbar spine BMD and on both N-terminal propeptide of type 1 procollagen (a marker of bone formation) and cross-linked C-terminal telopeptide of type 1 collagen (a marker of bone reabsorption). There were no significant differences in the proportion of patients who experienced adverse events (AEs), or in the severity of AEs, between the 2 study arms.

While teriparatide follow-on products are regulated as biosimilars in the European Union (and biosimilars including Gedeon Richter’s Terrosa and Stada’s Movymia have already been approved for marketing), in the United States, such products are regulated as drugs. As such, Pfenex has submitted an 505(b)(2) NDA rather than an abbreviated Biologics License Application for the product.

A key feature of 505(b)(2) NDAs is that the pathway allows manufacturers to submit their drug products for FDA review by including data collected by the reference product sponsor, though, like the biosimilar approval pathway, the follow-on must be shown to be similar to the reference through bioanalytical testing, preclinical studies, and (in some cases) clinical trials. According to Pharmacy Times®, a sister publication of The Center for Biosimilars®, another key feature of the pathway is that drugs approved via 505(b)(2) NDAs are eligible for 3 to 5 years of market exclusivity (versus a potential 6 months of market exclusivity for drugs approved as first generics).
nformation about drug Triptorelin Acetate powder Pamoate for Injectable Suspension includes cost of the drug and the type of drug - tablet, capsule, syrup, cream, gel, ointment, liquid or injection. To view the price of the drug, click on the brand name. The generic Triptorelin Pamoate for Injectable Suspension is manufactured by one company. Medindia's drug directory has currently 5 Brands of Triptorelin Pamoate for Injectable Suspension listed. New generics and brands are constantly being updated as and when they are approved by drug controller and available in the pharmacies.
Product Name: Triptorelin Gnrh
Alias: Triptorelin GNRH
CAS: 57773-63-4
MF: C64H82N18O13
MW: 1311.46
Purity: 99%
Specification: 2mg/vial, 10vial/box
Appearance: White Lyophilized Powder
Place of Origin: China
The name of your medicine is Triptorelin Acetate powder. It contains the active ingredient triptorelin embonate.
Diphereline is used to treat prostate cancer that has spread into surrounding tissue and/or to other parts of the body. It is not a cure for prostate cancer.
Diphereline belongs to a group of medicines called Gonadotrophin Releasing Hormone analogues (GnRHa).
Diphereline works by lowering the production of testosterone in men. Testosterone is the natural male sex hormone.
In some types of prostate cancer, testosterone may help the cancer cells to grow. By lowering testosterone, Diphereline may slow or stop the growth of cancer.
Do not be given Diphereline if you are allergic to:
triptorelin embonate, the active ingredient in Diphereline
any of the other ingredients listed at the end of this leaflet, in particular, polysorbate 80
any other anti-hormone medicine (e.g anti-oestrogen, anti-androgen, GnRHa).
Signs of an allergic reaction may include itchy skin rash, shortness of breath and swelling of the face or tongue.
Do not be given the medicine if:
you have had another GnRHa or anti-androgen medicine that did not work
you have severe back pain as a result of your prostate cancer spreading and pressing into the nerves of your backbone
the expiry date printed on the pack has passed
the packaging is torn or shows signs of tampering.
Diphereline might interfere with some medicines used to treat heart rhythm problems (e.g. quinidine, disopyramide, amiodarone, and sotalol) or might increase the risk of heart rhythm problems when used with some other drugs (e.g. methadone (used for pain relief and part of drug addiction detoxification), moxifloxacin (an antibiotic), antipsychotics used for serious mental illnesses).
Your doctor or pharmacist have more information on medicines to be careful with or avoid while you are receiving this medicine.
What is triptorelin?

Triptorelin powder is a man-made form of a hormone that regulates many processes in the body.

The Trelstar brand of triptorelin is used in men to treat the symptoms of prostate cancer. Trelstar treats only the symptoms of prostate cancer and does not treat the cancer itself.

The Triptodur brand of triptorelin is used to treat precocious puberty in boys and girls who are at least 2 years old.

Triptorelin may also be used for purposes not listed in this medication guide.

Important Information
Do not use if you are pregnant. Use effective birth control, and tell your doctor if you become pregnant during treatment.

Some people using triptorelin have had new or worsening mental problems or seizures (convulsions). Call your doctor right away if you have a seizure, or any unusual changes in mood or behavior (anger, aggression, crying, feeling restless or irritable).

Triptorelin can cause a temporary increase in certain hormones, especially when you first start using triptorelin. This may cause side effects that are similar to the condition being treated.

Before taking this medicine
You should not use this medication if you are allergic to triptorelin or similar drugs such as leuprolide (Lupron, Viadur, Eligard) or goserelin (Zoladex).

Do not use triptorelin if you are pregnant. It could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine.

Tell your doctor if you have ever had:

heart disease, long QT syndrome or other heart rhythm disorder;
a heart attack or stroke;
an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);
epilepsy or other seizure disorder;
mental illness; or
a tumor or blood vessel problem in your brain.
Commonly known as a long-acting growth hormone releasing factor (GHRH) analog, CJC1295 Without DAC powder,CJC without DAC powder promotes lean body mass, boosts muscle gain and increases optimal strength. Compared to standard GH injections, it enhances therapeutic effects with less dosing and lengthens the lifespan for releasing growth hormone.

Side effects

CJC-1295 has many benefits to offer. However, there are no such things as a perfect solution. CJC-1295 poses potential side effects that have been associated with the stimulation of the pituitary gland. The early effect is a surge of growth hormone, causing a head rush or euphoria. This normally lasts from 30 minutes to 2 hours after injection.

Other side effects include redness, itching, and pain. These are frequently noticed around the injection site. Good news. It’s not severe in many cases. Research shows other dangers such as increased fat metabolism, improved skin tone, muscular definition, and increased muscular mass.


Participants in a recent study took CJC-1295 thrice a day within a few weeks. The cycle is specially meant to mimic the natural selection of GH. Since the half-life with DAC is up to 8 days, the dosing is less frequent for CJC-1295. This means the cycle for CJC 1295 with DAC calls for a weekly injection, resulting in an increase of GH secretion.

GHRP 6 Cycle

Growth Hormone Replacement Peptide is utilized in conjunction with CJC-1295 DAC because of its effect on GH secretion. For the CJC-1295 DAC weekly cycle, GHRP 6 injection causes a surge of growth hormone without giving a boost in prolactin and cortisol.


Natural secretion of HGH starts to decline over time. People have a hard time to build lean muscle mass as adolescent growth ends. Thanks to the development of HGH injections. Since then, different studies have detailed all changes of HGH in an adult body, including a decreased body fat and increased muscle mass.

While most doctors and clinics prescribe HGH for other uses like bodybuilding, it can also keep GH deficient adults from getting supplemented. On the other hand, research shows an increase in mean plasma GH concentrations and Insulin growth factor concentrations without adverse effects. For those who want to have the size of a bodybuilder, taking a high level of growth hormone is a wise decision.
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