Tadarise 40 mg works by inhibiting the action of the enzyme phosphodiesterase type 5 (PDE5) in the body. During sexual stimulation, nitric oxide is released in the erectile tissue of the penis, which activates the enzyme guanylate cyclase. This enzyme increases levels of cyclic guanosine monophosphate (cGMP), leading to relaxation of smooth muscles in the corpus cavernosum of the penis and increased blood flow, resulting in an erection. https://www.flatmeds.com/product/tadarise-40-mg/